SALL4高表达在食管鳞癌临床病理及预后判定中的意义  

Significance of high expression of SALL4 in clinicopathological and prognostic judgment of esophageal squamous cell carcinoma

作　　者：卢俊蓉 王惠文[1] 何东风[1] LU Junrong;WANG Huiwen;HE Dongfeng(Department of Invasive Technology,Harbin Medical University Cancer Hospital,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院介入科,哈尔滨150086

出　　处：《实用肿瘤学杂志》2021年第5期420-425,共6页Practical Oncology Journal

基　　金：哈尔滨市科技创新人才研究专项基金(青年后备人才)(编号:2016RQQXJ228)。

摘　　要：目的分析食管鳞癌(Esophageal squamous cell carcinoma,ESCC)中SALL4的表达与临床病理及生存预后的关系,探讨SALL4在食管鳞癌诊断和治疗中的作用。方法收集2010年7月—2011年11月哈尔滨医科大学附属肿瘤医院90例食管鳞癌患者的癌组织及相应的癌旁组织,采用免疫组织化学的方法检测SALL4的表达情况,比较癌组织与癌旁组织间SALL4的表达差异,并分析其与食管鳞癌患者临床特征、总生存(Overall survival,OS)及无进展生存(Progression free survival,PFS)的关系。结果食管鳞癌组织中SALL4的表达水平明显高于癌旁组织(P<0.05),SALL4高表达与术中肿瘤部位(P=0.038)、G分级(P=0.036)和AJCC分期(P=0.015)密切关联。生存分析及Cox风险回归分析表明,SALL4高表达组的食管鳞癌患者OS和PFS均低于SALL4低表达组(P<0.05)。结论SALL4高表达可以作为食管鳞癌一个独立的预后判定因子,在临床工作中,可以帮助判断食管鳞癌患者的生存预后。Objective The aims of this study were to analyze the relationship between the expression of SALL4 in esophageal squamous cell carcinoma(ESCC)and clinicopathology and survival prognosis,and to explore the role of SALL4 in the diagnosis and treatment of esophageal squamous cell carcinoma.Methods Ninety patients with ESCC were treated in Harbin Medical University Cancer Hospital from July 2010 to November 2011.The expression of SALL4 was detected in ESCC and adjacent tissues by immunohistochemistry.Its relationship with clinical characteristics of patients with ESCC,overall survival(OS)and progression free survival(PFS)were analyzed.Results The expression of SALL4 in ESCC tissues was significantly higher than that in adjacent tissues.The high expression of SALL4 was closely related to intraoperative tumor site(P=0.038),G grade(P=0.036)and AJCC stage(P=0.015).Survival analysis and Cox risk regression analysis both showed that the OS and PFS of ESCC patients in the high expression of SALL4 group were lower than those in the low expression of SALL4 group.Conclusion The high expression of SALL4 can be used as an independent prognostic factor for ESCC.In clinical work,it can help judge the survival prognosis of patients with ESCC.

关 键 词：食管鳞癌 婆罗双树样基因4 表达分析 免疫组化 预后生物标记物 

分 类 号：R735.1[医药卫生—肿瘤]