CT多层灌注成像对直肠癌患者临床分期、TACE疗效评估的价值分析  

Value of CT Multi-slice Perfusion Imaging in Evaluating the Clinical Staging and Curative Effect of TACE in Patients with Rectal Cancer

作　　者：王忠耕[1] 宋瑞敏 甄亚平 WANG Zhonggen;SONG Ruimin;ZHEN Yaping(Xinxiang Central Hospital,Xinxiang,453000)

机构地区：[1]河南省新乡市中心医院,453000 [2]新乡医学院第四附属医院,453000

出　　处：《实用癌症杂志》2021年第10期1682-1685,共4页The Practical Journal of Cancer

摘　　要：目的探讨CT多层灌注成像对直肠癌患者临床分期、经导管动脉化学栓塞术(TACE)疗效评估的价值。方法选取直肠癌患者78例,对所有患者均行CT多层灌注成像检查,观察灌注参数:血流量、血容量、平均通过时间(MMT)、表面通透性(PS),根据患者临床分期的不同将其分为A组(A期,n=20)、B组(B期,n=18)、C组(C期,n=25)、D组(D期,n=15),观察比较A、B、C、D四组各灌注参数的差异,用Spearman法分析各灌注参数与直肠癌患者临床分期的相关性。根据TACE疗效的不同将其分为有效组(n=46)、无效组(n=32),观察比较有效组与无效组各灌注参数的差异,用ROC曲线分析两组中具有统计学差异的参数指标对TACE疗效的评估价值。结果A、B、C、D四组各灌注参数比较,血流量、血容量、MMT、PS差异均具有统计学意义(P<0.05)。相关性分析结果显示,血流量、血容量、MMT、PS均与直肠癌患者临床分期呈明显相关性(γ=0.256、-0.158、0.302、-0.173,P<0.05)。有效组与无效组各灌注参数比较,血流量、MMT差异具有统计学意义(P<0.05),血容量、PS差异无统计学意义(P>0.05)。ROC曲线分析结果显示,血流量、MMT及血流量联合MMT对直肠癌患者TACE疗效均具有评估价值(P<0.05),且血流量联合MMT的AUC大于血流量、MMT,差异均具有统计学意义(P<0.05)。结论CT多层灌注成像对直肠癌患者临床分期、TACE疗效均具有一定的评估价值,有望成为临床判断该病临床分期、疗效好坏的新指标。Objective To explore the value of CT multi-slice perfusion imaging in evaluating the clinical staging and curative effect of transcatheter arterial chemoembolization(TACE)in patients with rectal cancer.Methods A total of 78 patients with rectal cancer were enrolled.All underwent CT multi-slice perfusion imaging.Perfusion parameters[blood flow volume,blood volume,mean transit time(MMT),permeability surface(PS)]were observed.According to different clinical staging,they were divided into group A(stage A,n=20),group B(stage B,n=18),group C(stage C,n=25)and group D(stage D,n=15).The differences in all perfusion parameters were observed and compared among the 4 groups.The correlation between perfusion parameters and clinical staging of patients with rectal cancer was analyzed by Spearman.According to different curative effect of TACE,they were divided into effective group(n=46)and ineffective group(n=32).The differences in all perfusion parameters were observed and compared between effective group and ineffective group.The values of parameters with statistical differences for evaluating the curative effect of TACE was analyzed by ROC curves.Results There were significant differences in blood flow volume,blood volume,MMT and PS among groups A,B,C and D(P<0.05).The results of correlation analysis showed that blood flow volume,blood volume,MMT and PS were significantly correlated with the clinical staging of rectal cancer patients(γ=0.256,-0.158,0.302,-0.173,P<0.05).There were significant differences in blood flow volume and MMT between effective group and ineffective group(P<0.05),while there were no significant differences in blood volume and PS(P>0.05).The results of ROC curve analysis showed that blood flow volume,MMT and blood flow volume combined with MMT were all of value for evaluating the curative effect of TACE on patients with rectal cancer(P<0.05),and AUC of blood flow volume combined with MMT was greater than that of blood flow volume and MMT alone(P<0.05).Conclusion CT multi-slice perfusion imaging is of ce

关 键 词：CT多层灌注成像 直肠癌 临床分期 经导管动脉化学栓塞术 疗效评估 

分 类 号：R735.37[医药卫生—肿瘤]