近距离治疗技术在早期子宫内膜癌术后的应用进展  

Research progress on postoperative application of vaginal brachytherapy in patients with early endometrial carcinoma

作　　者：秦雪 晏俊芳[1] 杨波[1] 侯晓荣[1] 于浪[1] 邱杰[1] Qin Xue;Yan Junfang;Yang Bo;Hou Xiaorong;Yu Lang;Qiu Jie(Departments of Radiation Oncology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放疗科,100730

出　　处：《中华放射肿瘤学杂志》2021年第10期1089-1093,共5页Chinese Journal of Radiation Oncology

基　　金：科技部国家重点研发计划(2016YFC0105206);中国医学科学院中央级公益性科研院所基本科研业务费临床与转化医学研究基金(2019XK320046);北京协和医院青年科研基金(pumch201910569)。

摘　　要：放疗在早期子宫内膜癌术后患者的辅助治疗中具有重要作用。在有高中危复发风险的早期内膜癌患者中,阴道残端是最常见的复发部位。对于这部分患者,阴道近距离治疗(VBT)与外照射的局控率相近,但VBT的不良反应更轻。本文对VBT技术在早期子宫内膜癌术后的应用进展进行综述。分别从VBT的患者选择、阴道施源器的选择、放疗剂量分布的影响因素、影像引导的精准定位、放疗计划的制订和实施等方面进行详细阐述,并对近距离调强技术及新型质控仪器的应用进行介绍。Radiation therapy plays an important role in the adjuvant treatment of patients with early endometrial carcinoma.Vaginal stump is a common site of disease failure for early endometrial carcinoma patients with intermediate-high risk factors for recurrence.Compared with external beam radiotherapy,vaginal brachytherapy(VBT)can achieve comparable local control rate with fewer toxicities.In this article,research progresses upon the application of VBT in patients with early endometrial carcinoma after hysterectomy were investigated from multiple perspectives of the selection of patients,the selection of vaginal applicator,factors influencing dose distribution,image-guided adaptive brachytherapy,the design and implementation of radiotherapy regime.In addition,the application of intensity-modulated VBT and the usage of novel quality assurance equipment were also discussed.

关 键 词：子宫内膜肿瘤/近距离疗法 研究进展 

分 类 号：R737.33[医药卫生—肿瘤]