抗艾滋病药物洛匹那韦的合成及结构表征  

Synthesis and Structural Characterization of the Anti-AIDS Drug Lopinavir

作　　者：孙远东[1] 何勇 高永好 杨士伟 司友琳[1] SUN Yuandong;HE Yong;GAO Yonghao;YANG Shiwei;SI Youlin(Bengbu Medical College,Bengbu Anhui 233030,China;Hefei Huafang Pharmaceutical Technology Co.,Ltd.,Hefei 230088,China)

机构地区：[1]蚌埠医学院,安徽蚌埠233030 [2]合肥华方医药科技有限公司,安徽合肥230088

出　　处：《佳木斯大学学报（自然科学版）》2021年第5期111-114,共4页Journal of Jiamusi University：Natural Science Edition

基　　金：安徽省教育厅自然科学项目(KJ2020A0885);安庆医药高等专科学校混合式教学改革研究项目(2019HK015)。

摘　　要：以二氯甲烷为溶剂,DMF作为添加剂,反应温度为50℃,反应时间为4h,可获得洛匹那韦利中间体(I),反应收率达80%。以DMF为溶剂,EDCI作为添加剂,反应温度为25℃,反应时间为24h,可获得洛匹那韦利,反应收率达83%,HPLC检测,纯度为99.76%.With dichloromethane as solvent and DMF as additive,the reaction temperature is 50℃and the reaction time is 8 hours,and the reaction yield is 80%.With DMF as solvent,EDCI as additive,reaction temperature is 25℃,reaction time is 24 hours,Lopinaville can be obtained.Reaction yield is 83%,HPLC test,purity is 99.76%.

关 键 词：洛匹那韦 合成 结构表征 

分 类 号：TQ460.6[化学工程—制药化工]