转录因子激活蛋白-2a在老年肺腺癌病人中的表达情况及与临床病理参数的相关性  

Expression of transcription factor activator protein-2a in elderly patients with lung adenocarcinoma and its relationship with clinicopathological parameters

作　　者：方乐平 董振 樊卫飞 FANG Le-ping;DONG Zhen;FAN Wei-fei(Department of Hematology Oncology,Geriatric Hospital of Nanjing Medical University,Nanjing 210024,China;Department of Radiotherapy,BenQ Medical Center Affiliated to Nanjing Medical University,Nanjing 222023,China)

机构地区：[1]南京医科大学附属老年医院血液肿瘤科,江苏省南京市210024 [2]南京医科大学附属明基医院放疗科,江苏省南京市222023

出　　处：《实用老年医学》2021年第10期1036-1039,1044,共5页Practical Geriatrics

基　　金：南京医科大学科技发展基金资助项目(NMUB2018181)。

摘　　要：目的探讨转录因子激活蛋白-2a(TFAP-2a)在老年肺腺癌病人中的表达情况及与临床病理参数的相关性。方法通过生物信息学数据挖掘TFAP-2a在肺腺癌组织与正常肺组织中的表达差异及其对肺腺癌预后的影响;收集2015年8月至2020年3月切除的64份老年肺腺癌组织标本及25份老年正常肺组织标本,采用免疫组化染色法测定TFAP-2a的表达情况,分析老年肺腺癌组织中TFAP-2a的表达水平与临床病理参数的相关性。结果GEPIA数据库分析结果显示,肺腺癌组织中TFAP-2a的表达量显著高于正常肺组织(P<0.05),但TFAP-2a的表达水平与肺腺癌的TNM分期无关(P>0.05)。KMplot数据库分析结果显示,TFAP-2a低表达的肺腺癌病人的无复发生存期和总生存期相较于高表达病人明显获益(均P<0.05)。免疫组化染色结果显示,老年肺腺癌组织TFAP-2a高表达的比例显著高于老年正常肺组织(P<0.01),并且在有淋巴结转移及中-低分化的老年肺腺癌病人中,TFAP-2a高表达的比例更高(P<0.05)。结论TFAP-2a在老年肺腺癌病人中呈高表达,过表达TFAP-2a的老年肺腺癌分化更差,更易发生淋巴结转移。Objective To investigate the expression of transcription factor activator protein-2a(TFAP-2a)in the elderly patients with lung adenocarcinoma and its relationship with clinicopathological parameters.Methods The difference of TFAP-2a expression between lung adenocarcinoma and normal lung tissue and its effect on the prognosis of lung adenocarcinoma were analyzed by bioinformatics data.A total of 64 cases of elderly lung adenocarcinoma tissue and 25 cases of elderly normal lung tissue were collected from August 2015 to March 2020,and the expression of TFAP-2a was detected by immunohistochemical staining,and the correlation between TFAP-2a expression and clinicopathological parameters was analyzed.Results The GEPIA database analysis results showed that the expression level of TFAP-2a in lung adenocarcinoma tissue was significantly higher than that in normal lung tissue(P<0.05),but there were no significant differences among lung adenocarcinoma tissues with different TNM staging(P>0.05).KMplot database analysis results showed that the progression-free survival and overall survival of the patients with lung adenocarcinoma with low expression of TFAP-2a were better than those with high expression of TFAP-2a(all P<0.05).The immunohistochemical staining results showed that the proportion of high expression of TFAP-2a in the elderly lung adenocarcinoma tissue was significant higher than that in the elderly normal lung tissue(P<0.01),and the proportion of high expression of TFAP-2a in the elderly patients with lung adenocarcinoma who had lymph node metastasis and moderate-low differentiation was higher(P<0.05).Conclusions TFAP-2a is highly expressed in the elderly patients with lung adenocarcinoma.The lung adenocarcinoma with over expression of TFAP-2a is poorer in differentiation and more prone to lymph node metastasis.

关 键 词：转录因子激活蛋白-2a 肺腺癌 预后 生物信息学 

分 类 号：R734.2[医药卫生—肿瘤]