华中地区汉族人群SREBF1基因多态性与帕金森病的相关性分析  

Correlation between SREBF1 Gene Polymorphism and Parkinson’s Disease in the Han Population of Central China

作　　者：韩超[1,2] 余勤薇 孙雅迪 吴佳薇 李雲娜 黄金莎 HAN Chao;YU Qin-wei;SUN Ya-di;WU Jia-wei;LI Yun-na;HUANG Jin-sha(Department of Neurology,the First Affiliated Hospital of University of Science and Technology of China,Heifei 230001,China;Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Sci-ence and Technology,Wuhan 430030,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)神经内科,合肥230001 [2]华中科技大学同济医学院附属协和医院神经内科,武汉430022

出　　处：《神经损伤与功能重建》2021年第10期569-571,575,共4页Neural Injury and Functional Reconstruction

基　　金：国家重点研发计划(No.2017YF C1310200);中国睡眠研究会豪森科研项目(No.2019HSA02);安徽省自然科学基金(No.2008085QH366);中央高校基本科研业务费专项资金(No.WK9110000081)。

摘　　要：目的:探索华中地区SREBF1基因突变位点SNP rs11868035与帕金森病(PD)的相关性。方法:本研究纳入471例华中地区原发性PD患者和536例健康对照者,均为汉族。检测PD组和对照组及各亚组间rs11868035位点等位基因和基因型频率。行文献检索及Meta分析,进一步探索rs11868035位点变异与中国人群PD易患性的关联。结果:SNP rs11868035位点共3种基因型(AA/AG/GG);PD组与对照组、各亚组之间等位基因频率差异、基因型差异无统计学意义(P>0.05)。Meta分析结果示该位点与中国人群PD发病可能无明显相关性。结论:华中地区汉族人群SREBF1基因突变位点rs11868035与PD发病可能无相关性。Objective:To explore the correlation of the SREBF1 gene SNP rs11868035 with Parkinson’s disease(PD)in the Han population of central China.Methods:We included 471 patients with idiopathic PD and 536 healthy controls,all of Han ethnicity,in this study,and compared the rs11868035 allele and genotype frequency differences between the two groups.A meta-analysis was conducted to further evaluate the correlation between rs11868035 and the incidence of PD in the Chinese population.Results:There were 3 genotypes(AA/AG/GG)of SNP rs11868035.There was no significant difference in allele frequency nor genotype between the PD group and control group(P>0.05).The meta-analysis showed that there might be no significant correlation between this site and PD incidence in the Chinese population.Conclusion:The SREBF1 gene SNP rs11868035 might not be corre-lated with the incidence of PD in the Han population of central China.

关 键 词：帕金森病 基因多态性 SREBF1基因 rs11868035位点 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]