磁共振IVIM与宫颈鳞癌微血管密度相关性分析  

Correlation analysis of MRI IVIM and microvessel density of cervical squamous cell carcinoma

作　　者：黄文亮[1] 吴淑芬[2] 周山[1] 赵路 金少举[4,5] HUANG Wenliang;WU Shufen;ZHOU Shan;ZHAO Lu;JIN Shaoju(MRI Room,the Second Affiliated Hospital of Luohe Medical College,Luohe,Henan 462300,China;Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Luohe Medical College,Luohe,Henan 462300,China;Department of Pathology,the Second Affiliated Hospital of Luohe Medical College,Luohe,Henan 462300,China;Department of Pharmacology,Luohe Medical College,Luohe,Henan 462002,China;Innovative Science and Technology Team of Tumor Occurrence and Prevention Research in Henan,Luohe,Henan 462002,China)

机构地区：[1]漯河医学高等专科学校第二附属医院MRI室,河南漯河462300 [2]漯河医学高等专科学校第二附属医院妇产科,河南漯河462300 [3]漯河医学高等专科学校第二附属医院病理科,河南漯河462000 [4]漯河医学高等专科学校药学系,河南漯河462002 [5]河南省肿瘤发生与防治研究创新型科技团队,河南漯河462002

出　　处：《重庆医学》2021年第19期3342-3345,共4页Chongqing medicine

基　　金：漯河医学高等专科学校创新创业发展能力提升工程科研类项目(2019-LYZKYZD012);河南省漯河市科技创新项目(20181000009)。

摘　　要：目的探讨对比体素内不相干运动(IVIM)定量参数与宫颈鳞癌患者免疫组织化学方法CD31染色标记的宫颈鳞癌微血管密度(MVD)的相关性。方法30例病理证实的宫颈鳞癌患者术前均行盆腔磁共振成像(MRI)常规序列及IVIM序列扫描,经图像后处理软件得到纯水分子扩散系数D值、与灌注相关的扩散系数D*值、灌注指数f值;术后行宫颈鳞癌肿瘤免疫组织化学及MVD计算,分析D、D*、f值与CD31标记的宫颈鳞癌中MVD的相关性。结果宫颈鳞癌D值为(0.78±0.06)×10^(-3) mm^(2)/s,D*值为(12.57±1.22)×10^(-3) mm^(2)/s,f值为(23.34±1.64)%,CD31标记的MVD为16.50±5.24,D值与CD31标记MVD呈负相关(r=-0.830,P<0.001),D*、f值CD31标记MVD呈正相关(r=0.889、0.897,P<0.001)。结论D值与MVD呈负相关,D*、f值与MVD呈正相关,D、D*、f值可成为反映宫颈鳞癌MVD的无创影像学检查指标。Objective To explore the correlation between the quantitative parameters of intravoxel incoherent movement(IVIM)and micro-vessel density(MVD)in cervical squamous cell carcinoma labeled by the immunohistochemical method with the CD31 staining.Methods Thirty patients with the cervical squamous cell carcinoma underwent the pelvic MRI routine sequence and IVIM sequence scanning before operation,and the values of D,D*and f were obtained after the image post-processing.Immunohistochemistry was conducted and MVD of cervical squamous cell carcinoma were calculated after operation to analyze the correlation between D,D*,f values and CD31-labeled MVD of cervical squamous cell carcinoma.Results The values of the D,D*,f,CD31-labeled MVD of cervical squamous cell carcinoma were(0.78±0.06)×10^(-3) mm^(2)/s,(12.57±1.22)×10^(-3) mm^(2)/s,(23.34±1.64)%and 16.50±5.24,respectively.The D value was negatively correlated with the CD31-labeled MVD(r=-0.830,P<0.001).The D*value and f value were positively correlated with the CD31-labeled MVD(r=0.889,0.897,P<0.001).Conclusion The D value is negatively correlated with MVD.D*value and f value are positively correlated with the MVD.The values of D,D*,f can be usded as the non-invasive imaging indicators to reflect the MVD of cervical squamous cell carcinoma.

关 键 词：宫颈癌 体素内不相干运动 微血管密度 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]