使用EP化疗联合放疗的广泛期小细胞肺癌患者不同BMI与预后的关系分析  

Relationship between BMI and prognosis in patients with extensive-stage small-cell lung cancer treated with EP chemotherapy combined local radiotherapy

作　　者：张翔 姜莹莹 何康 施玥 薛婧婧 田海霞 季敏 王晓华[3] 陈诚[2] ZHANG Xiang;JIANG Yingying;HE Kang;SHI Yue;XUE Jingjing;TIAN Haixia;JI Min;WANG Xiaohua;CHEN Cheng(Department of Pharmacy,the Second Hospital of Nanjing/Nanjing Cancer Hospital,Nanjing 210003,China;Department of Radiation,the Affiliated Cancer Hospital of Nanjing Medical University/Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research,Nanjing 210009,China;Department of Medical Oncology,the Affiliated Cancer Hospital of Nanjing Medical University/Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research,Nanjing 210009,China)

机构地区：[1]南京市第二医院(南京市肿瘤医院)药剂科,江苏南京210003 [2]南京医科大学附属肿瘤医院(江苏省肿瘤医院,江苏省肿瘤防治研究所)放疗科,江苏南京210009 [3]南京医科大学附属肿瘤医院(江苏省肿瘤医院,江苏省肿瘤防治研究所)肿瘤内科,江苏南京210009

出　　处：《中国肿瘤外科杂志》2021年第5期489-493,共5页Chinese Journal of Surgical Oncology

基　　金：江苏省肿瘤医院基金项目(ZM201814)。

摘　　要：目的分析广泛期小细胞肺癌(ES-SCLC)患者使用EP方案(依托泊苷联合铂类)化疗联合胸部局部放疗,不同身体质量指数(BMI)与预后之间的关系,为早期营养干预健康管理提供理论依据。方法回顾性分析2010年1月至2019年12月江苏省肿瘤医院收治的110例接受标准EP方案化疗联合局部放疗ES-SCLC患者BMI与其生存时间的关系。结果110例患者中BMI为21.5~24.0,24.1~28.0患者OS较BMI<21.5的患者总生存期(OS)显著延长,分别为30.0、29.0和20.0个月,差异有统计学意义(P<0.01)。美国东部肿瘤协作组(ECOG)标准评分1分组与2分组患者相比,中位OS也显著延长,两组OS分别为27.0个月和12.0个月,差异有统计学意义(P<0.01)。结论BMI>21.5、ECOG评分为1的ES-SCLC患者接受化疗联合局部放疗能取得生存获益,提示早期营养干预和健康管理可以提高患者生活质量及生存时间。Objective To analyze the relationships of BMI and prognosis in the patients with extensive-stage small-cell lung cancer(ES-SCLC)who received EP chemotherapy combined local thoracic radiotherapy,so as to provide theoretical basis for early nutritional intervention.Methods A retrospective analysis was carried out from January 2010 to December 2019 in 110 ES-SCLC patients treated with EP chemotherapy combined with local radiotherapy,aiming at exploring the correlation between BMI and overall survival(OS).Results The patients whose BMI ranged from 21.5 kg/m2 to 28.0 kg/m2 had longer OS compared with the ones that BMI<21.5 kg/m2 significantly(P<0.01).The median overall survival of patients with 1 score of ECOG was significantly longer than that in the patients with 2 score of ECOG(27.0 months vs 12.0 months,P<0.01).Conclusions The ES-SCLC patients whose BMI>21.5 and ECOG=1 have longer OS time.And early nutrition intervention and health management can improve the quality of life and prolong the survival time of patients.

关 键 词：广泛期小细胞肺癌 EP化疗 局部放疗 身体质量指数 总生存期 

分 类 号：R73[医药卫生—肿瘤]