基线^(18)F-FDG PET/CT最大标准摄取值与B细胞非霍奇金淋巴瘤临床疗效及预后的关系  

The efficacy and prognostic value of maximum standard uptake on baseline ^(18)F-FDG PET/CT in B-cell non-Hodgkin's lymphoma

作　　者：郭晓川 张伟京 王斌 王伟霞 黄乐富 曹宝平 仲凯励 Guo Xiaochuan;Zhang Weijing;Wang Bin;Wang Weixia;Huang Lefu;Cao Baoping;Zhong Kaili(Department of Lymphoma,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院淋巴肿瘤科,北京100038

出　　处：《首都医科大学学报》2021年第5期829-835,共7页Journal of Capital Medical University

摘　　要：目的评估18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像/电子计算机断层扫描(^(18)F-flurodeoxyglucose positron emission tomography/computed tomography,^(18)F-FDG PET/CT)的最大标准化摄取值(maximum standard uptake value,SUV_(max))与B细胞非霍奇金淋巴瘤的疗效及预后的关系。方法分析2016年8月至2019年9月于首都医科大学附属北京世纪坛医院收治的初治弥漫大B细胞淋巴瘤及滤泡性淋巴瘤患者共47例,评估基线SUV_(max)与各临床病理因素、实验室化验指标之间的相关性,用受试者工作特征(receiver operating characteristic,ROC)曲线分析法确定基线SUV_(max)对疾病进展的最佳临界点,分析其对治疗疗效及生存的预后、预测价值。结果①乳酸脱氢酶(lactic dehydrogenase,LDH)浓度、1年内有无进展、病理类型组别中的基线SUV_(max)均值差异有统计学意义;②以1年进展率为截点,ROC曲线上SUV_(max)最佳临界点为14.4,以14.4为界限值进行分组,发现SUV_(max)<14.4组患者中位无进展生存时间(progression-free survival,PFS)、中位总生存期(overall survival,OS)均远远高于SUV_(max)≥14.4组;③以随访结束后患者疾病进展为截点,SUV_(max)最佳临界点为16.7,以16.7为界限值进行分组,发现SUV_(max)<16.7组患者中位PFS远高于SUV_(max)≥16.7组(P=0.025)。结论B细胞型非霍奇金淋巴瘤患者的基线SUV_(max)与疗效及生存预后有密切关系,具有很大的临床应用价值。Objective To evaluate the efficacy and prognostic value of maximum standardized uptake(SUV_(max))of ^(18)F-flurodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)in B-cell non-Hodgkin s lymphoma(NHL).Methods A total of 47 patients with B-cell non-Hodgkin s lymphoma treated in Beijing Shijitan Hospital,Capital Medical University from August 2016 to September 2019 were retrospectively analyzed.The correlation between baseline SUV_(max) and clinicopathological factors,laboratory indexes was evaluated.Receiver operating characteristic(ROC)curve analysis was used to determine the optimal point of SUV_(max) for disease progression,and the prognostic value of SUV_(max) was analyzed.Results①There were significant differences between the baseline SUV_(max) and lactic dehydrogenase(LDH)level,progression status within 1 year,pathological types,respectively;②Take the 1-year progression rate as the cut-off point,the optimal point of SUV_(max) was 14.4,the median progression-free survival(PFS)and overall survival(OS)of patients with SUV_(max)<14.4 were significantly higher than those with SUV_(max)≥14.4,P<0.05;③Take the disease progression as the cut-off point,the optimal pointof SUV_(max) was 16.7,the median PFS of patients with SUV_(max)<16.7 were significantly higher than those with SUV_(max)≥16.7,P=0.025.Conclusion Baseline SUV_(max) of patients with B-cell lymphoma is closely related to the curative effect and survival,which has great clinical value.

关 键 词：B细胞型非霍奇金淋巴瘤 18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像 最大标准化摄取值 无进展生存时间 总生存期 

分 类 号：R733[医药卫生—肿瘤]