血管生成素样蛋白2及核转录因子表达与急性脑梗死患者脑水肿的关系  

Relationship of serum ANGPTL2 level and NF-κB expression with cerebral edema in ACI patients

作　　者：吴慧芬[1] 贝筝 叶苗苗[2] 郑芳昆 邢增娈 Wu Huifen;Bei Zheng;Ye Miaomiao;Zheng Fangkun;Xing Zengluan(Department of Neurology,Hainan Geriatrics Hospital,Haikou 571100,Hainan Province,China)

机构地区：[1]海南省干部疗养院,海南省老年病医院神经内科,海口571100 [2]海南省干部疗养院,海南省老年病医院内分泌科,海口571100

出　　处：《中华老年心脑血管病杂志》2021年第10期1063-1065,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：海南省自然科学基金面上项目(817373)。

摘　　要：目的探讨血清血管生成素样蛋白2(ANGPTL2)和外周血单核细胞NF-κB mRNA表达预测急性脑梗死(ACI)患者脑水肿的价值。方法选取本院收治的ACI患者240例,根据头颅CT检查分为脑水肿组58例和对照组182例。ELISA法测血清ANGPTL2水平,RT-PCR法测NF-κB mRNA表达。采用多因素logistic回归分析脑水肿的影响因素,绘制ROC曲线分析两者预测脑水肿的价值。结果脑水肿组血清ANGPTL2和NF-κB mRNA表达高于对照组(P=0.000)。多因素logistic回归分析显示,血清ANGPTL2和NF-κB mRNA表达是脑水肿影响因素(P<0.05)。血清ANGPTL2和NF-κB mRNA表达预测脑水肿的ROC曲线下面积0.887、0.823,均有预测价值。结论血清ANGPTL2及单核细胞NF-κB mRNA表达是ACI患者脑水肿影响因素,可早期预测脑水肿。Objective To study the value of serum ANGPTL2 level and NF-κB mRNA expression in PBMC for predicting cerebral edema in ACI patients.Methods Two hundred and forty ACI patients admitted to our hospital were divided into cerebral edema group(n=58)and control group(n=182)according to their head CT findings.Their serum ANGPTL2 level was measured by ELISA and their NF-κB mRNA expression was detected by RT-PCR.The influencing factors of cerebral edema were analyzed by multivariate logistic regression analysis.The value of serum ANGPTL2 level and NF-κB mRNA expression in PBMC for predicting cerebral edema in ACI patients was analyzed by ROC curve analysis.Results The serum ANGPTL2 level and NF-κB mRNA expression level were significantly higher in cerebral edema group than in control group(P=0.000).Multivariate logistic regression analysis showed that serum ANGPTL2 level and NF-κB mRNA expression level were influence factors of cerebral edema in ACI patients(P<0.05).The AUC of serum ANGPTL2 level and NF-κB mRNA expression level for predicting cerebral edema in ACI patients was 0.887(95%CI:0.770-1.000)and 0.823(95%CI:0.679-0.968)respectively.Conclusion Serum ANGPTL2 level and NF-κB mRNA expression level are the influencing factors of cerebral edema and can thus predict early cerebral edema in ACI patients.

关 键 词：血管生成素2 NF-ΚB 脑梗死 单核细胞 RNA 信使 

分 类 号：R743.33[医药卫生—神经病学与精神病学]