雌激素及其受体影响胆固醇结石形成的研究进展  

Research progress of effect of estrogen and its receptors on cholesterol gallstone disease

作　　者：庄谦 董志霞 宛新建 ZHUANG Qian;DONG Zhi-xia;WAN Xin-jian(Digestive Endoscopic Center,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院消化内镜中心,上海200233

出　　处：《上海交通大学学报（医学版）》2021年第10期1394-1396,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科技创新行动计划(19411951500)。

摘　　要：胆固醇结石是消化系统常见病、多发病。胆汁中胆固醇过饱和及胆囊收缩功能障碍是胆固醇结石形成的重要病理生理机制。雌激素及其受体可通过调节胆固醇和胆汁酸代谢及胆囊收缩功能等机制影响胆固醇结石的形成。经典核受体(如雌激素受体α、雌激素受体β)以及新型膜受体(如G蛋白偶联受体30)在胆固醇结石形成中均发挥重要作用。针对雌激素受体设计合成选择性拮抗剂可能是潜在的胆固醇结石防治策略。该文主要对近年来雌激素及其受体影响胆固醇结石形成的研究进展进行综述。Gallstone disease is a common disorder of the digestive system.Cholesterol supersaturation in bile and gallbladder contraction dysfunction are important pathophysiological mechanisms of cholesterol gallstone formation.Estrogen and its receptors can affect cholesterol gallstone formation through regulating cholesterol and bile acid metabolism and gallbladder contraction.Classical nuclear receptors such as estrogen receptorαand estrogen receptorβ,as well as novel membrane receptors such as G protein-coupled receptor 30,play an important role in cholesterol gallstone formation.The design and synthesis of selective antagonists targeting estrogen receptors may be a potential strategy for the prevention and treatment of cholesterol gallstone disease.In this paper,the research progress of effect of estrogen and its receptors on cholesterol gallstone disease in recent years is reviewed.

关 键 词：胆固醇结石 雌激素 雌激素受体 胆固醇 胆汁酸 

分 类 号：R575.62[医药卫生—消化系统]