阿帕替尼治疗恶性胸腔、腹腔积液的临床观察  

Clinical Observation of Apatinib in the Treatment of Malignant Pleuroperitoneal Effusion

作　　者：孔霞 姜巩 魏军功 高玉芹 KONG Xia;JIANG Gong;WEI Jungong;GAO Yuqin(Department of Oncology,Shanxian Central Hospital,Heze 274300,China)

机构地区：[1]山东省单县中心医院肿瘤科,山东菏泽274300

出　　处：《中国医药指南》2021年第27期114-115,118,共3页Guide of China Medicine

摘　　要：目的观察阿帕替尼对恶性胸腔、腹腔积液的临床疗效。方法选择恶性胸腔、腹腔积液患者共40例,随机分为两组,各20例。试验组患者采用阿帕替尼治疗,对照组采用常规顺铂胸腔灌注化疗。评价两组患者临床疗效(积液深度变化)、不良反应。结果试验组患者有效率(45%)及疾病控制率(85%)均高于对照组(40%、75%),试验组治疗后积液深度减少平均值高于对照组,差异均无统计学意义(P>0.05)。不良反应方面,试验组及对照组均未出现Ⅲ~Ⅳ级不良反应,试验组高血压、肝功能异常、白细胞减少、贫血、血小板减少、腹泻、口腔溃疡发生率高于对照组,恶心及治疗相关性疼痛发生率低于对照组,但差异均无统计学意义(P>0.05)。结论阿帕替尼治疗恶性胸腔、腹腔积液的疗效与常规治疗方法相当,不良反应可耐受。Objective To observe the clinical effect of apatinib on malignant pleural and peritoneal effusion.Methods Forty cases of malignant pleural or peritoneal effusion were selected and randomly divided into two groups,20 cases each.Patients in the experimental group were treated with apatinib,while those in the control group were treated with conventional cisplatin infusion chemotherapy.The clinical efficacy(change of effusion depth)and toxic effects of the two groups were evaluated.Results The effective rate(45%)and disease control rate(85%)in the experimental group were higher than those in the control group(40%,75%),and the mean decrease of effusion depth in the experimental group was higher than that in the control group,all those differenceswere not statistically significant(P>0.05).The experimental group and control group were not present levelⅢ-Ⅳside effects.The incidence of hypertension,liver dysfunction,leukopenia,anemia,thrombocytopenia,diarrhea and oral ulcer in the experimental group was higher than that in the control group,and the incidence of nausea and treatment-related painwas lower than that in the control group,but the differences were not statistically significant(P>0.05).Conclusion The efficacy of apatinib in the treatment of malignant pleural and peritoneal effusion is comparable to that of conventional treatment with tolerable side effects.

关 键 词：阿帕替尼 恶性积液 肿瘤 灌注化疗 

分 类 号：R730.6[医药卫生—肿瘤]