原发性胆汁性胆管炎患者中枢神经系统改变相关研究进展  

Research advances in central nervous system changes in patients with primary biliary cholangitis

作　　者：胡一男 尚玉龙 周新民 HU Yinan;SHANG Yulong;ZHOU Xinming(Department of Gastroenterology,Xijing Hospital,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院消化内科,西安710032

出　　处：《临床肝胆病杂志》2021年第10期2269-2271,共3页Journal of Clinical Hepatology

摘　　要：原发性胆汁性胆管炎(PBC)是一种以胆汁淤积为主要表现的自身免疫性肝病,好发于中老年女性。大约50%的患者伴有乏力和瘙痒,20%的患者伴有抑郁或者情绪的改变。近年有研究证明,PBC患者非特异性症状如乏力、瘙痒以及认知改变等症状与中枢神经系统结构和功能改变存在联系。通过大脑影像学改变及早期发现临床前期的PBC患者,可能成为该病早期诊断的检查手段。Primary biliary cholangitis(PBC)is an autoimmune liver disease manifesting as cholestasis and is often observed in the middle-aged and elderly women.About 50%of the patients have fatigue and itching,and 20%have depression or mood changes.In recent years,a number of studies have shown that the non-specific symptoms of patients with primary biliary cholangitis(PBC),such as fatigue,itching,and cognitive changes,are associated with the structural and functional changes of the central nervous system.Early identification of preclinical PBC patients through brain imaging changes may be one of the ways for the early diagnosis of this disease.

关 键 词：肝硬化 胆汁性胆管炎 中枢神经系统 磁共振成像 

分 类 号：R575.22[医药卫生—消化系统]