调节性T淋巴细胞/辅助性T淋巴细胞17在自身免疫性肝炎发生发展中的作用机制及其相关治疗靶点  

Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets

作　　者：董雯迪 张海蓉[1] 李瑞[1] 张宇艳 朱婕 DONG Wendi;ZHANG Hairong;LI Rui;ZHANG Yuyan;ZHU Jie(Department of Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院消化内科,昆明650032

出　　处：《临床肝胆病杂志》2021年第10期2456-2460,共5页Journal of Clinical Hepatology

摘　　要：自身免疫性肝炎(AIH)病因及发病机制尚不明确,目前认为其与遗传易感性、环境因素等相互作用有关。调节性T淋巴细胞(Treg)主要通过分泌IL-10和TGFβ发挥免疫抑制功能,辅助性T淋巴细胞(Th)17主要促进炎症反应,提示Treg和Th17及两者动态平衡可能参与AIH的发生发展,但其参与机制仍需进一步探讨。综述了近年来Treg/Th17与AIH的相关性,并对其作用机制、治疗靶点作一阐述。The etiology and pathogenesis of autoimmune hepatitis(AIH)remain unclear and are currently considered to be associated with genetic susceptibility and environmental factors.Regulatory T(Treg)cells play an immunosuppressive role by secreting IL-10 and TGFβ,while T helper 17(Th17)cells mainly promote inflammatory response,suggesting that Treg cells,Th17 cells,and the dynamic balance between them may be involved in the development and progression of AIH;however,further studies are needed to explore related participation mechanisms.This article reviews the association between Treg/Th17 cells and AIH in recent years and elaborates on their mechanism of action and therapeutic targets.

关 键 词：肝炎 自身免疫性 T淋巴细胞 调节性 T淋巴细胞 辅助诱导 

分 类 号：R575.1[医药卫生—消化系统]