利培酮治疗精神分裂症的疗效与多巴胺D2受体基因多态性的关系  

Relationship between the Efficacy of Risperidone in the Treatment of Schizophrenia and Dopamine D2 Receptor Gene Polymorphism

作　　者：余相满 李志华 YU Xiang-man;LI Zhi-hua(Ankang Central Hospital,Ankang Shaanxi,725000)

机构地区：[1]安康市中心医院药剂科,陕西安康725000

出　　处：《医学临床研究》2021年第9期1389-1391,1395,共4页Journal of Clinical Research

摘　　要：【目的】探讨利培酮治疗精神分裂症的疗效与多巴胺D2受体基因(DRD2)多态性的关系。【方法】选取2018年10月至2019年10月本院收治的68例精神分裂症患者为研究对象,均口服利培酮治疗8周,采用阳性与阴性症状量表(PANSS)评估利培酮的疗效,根据PANSS评分为总疗效有效组与无效组、阴性症状疗效有效组与无效组、阳性症状疗效有效组与无效组。采用单核苷酸多态性技术(SNP)检测68例患者DRD2受体基因上rs6275、rs6277等位点的基因型和等位基因频率。【结果】68例患者治疗后总分、阳性症状评分、阴性症状评分、一般精神病理较治疗前显著降低,差异有统计学意义(P<0.05)。利培酮治疗精神分裂症总疗效有效52例、无效16例;阳性症状有效54例、无效14例;阴性症状有效53例、无效15例。不同疗效组间患者性别、年龄、病程比较,差异无统计学意义(P>0.05)。rs6275位点不同基因型在总疗效有效组与无效组比校,CC、CT、TT及等位基因C、T的分布比较,差异均有统计学意义(P<0.05)。rs6277位点不同基因型在在总疗效有效组与无效组、阳性症状有效组与无效组中CC、CT、TT及等位基因C、T的分布比较,差异均有统计学意义(P<0.05)。【结论】DRD2基因多态性与利培酮治疗精神分裂症的临床疗效相关,可根据不同DRD2基因多态性给予精神分裂症患者个体化的用药方案。【Objective】To investigate the relationship between the efficacy of risperidone in the treatment of schizophrenia and the polymorphism of dopamine D2 receptor gene(DRD2).【Methods】A total of 68 schizophrenic patients treated in our hospital from October 2018 to October 2019 was selected as the research objects.They were treated with risperidone for 8 weeks.The efficacy of risperidone was evaluated by positive and negative symptom scale(PANSS).According to PANSS,they were divided into total effective group and ineffective group,negative symptom effective group and ineffective group,positive symptom effective group and ineffective group.The genotypes and allele frequencies of rs6275 and rs6277 in DRD2 receptor gene of 68 patients were detected by single nucleotide polymorphism(SNP).【Results】The total score,positive symptom score,negative symptom score and general psychopathology of 68 patients after treatment were significantly lower than those before treatment(P<0.05).Risperidone was effective in 52 cases and ineffective in 16 cases;Positive symptoms were effective in 54 cases and ineffective in 14 cases;Negative symptoms were efr fective in 53 cases and ineffective in 15 cases.There was no significant difference in gender,age and course of disease a-mong different treatment groups(P>0.05).There were significant differences in the total efficacy of different genotypes of rs6275 between the effective group and the ineffective group,as well as the distribution of CC,CT,TT and alleles C and T(P<0.05).There were significant differences in the total efficacy of different genotypes of rs6277 between the ef fective group and the ineffective group,and the distribution of CC,CT,TT and allele C and T positive symptoms between the effective group and the ineffective group(P<0.05).【Conclusion】DRD2 gene polymorphism is related to the clinical efficacy of risperidone in the treatment of schizophrenia.Individualized drug regimens can be given to schizophrenic patients according to different DRD2 gene polymorphisms.

关 键 词：神分裂症/药物疗法 利哌立酮/治疗应用 受体 多巴胺D2/遗传学 基因表达 多态现象 遗传 

分 类 号：R749.3[医药卫生—神经病学与精神病学]