喉鳞状细胞癌生物标志物的研究进展  

Research Advances in Biomarkers of Laryngeal Squamous Cell Carcinoma

作　　者：沈海龙 朱君伟 韩燕勋 王大明[1] 刘业海[1] SHEN Hailong;ZHU Junwei;HAN Yanxun;WANG Daming;LIU Yehai(Department of Otorhinolaryngology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,230032,China)

机构地区：[1]安徽医科大学第一附属医院耳鼻咽喉头颈外科,合肥230032

出　　处：《中国中西医结合耳鼻咽喉科杂志》2021年第5期395-400,共6页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：安徽省教育厅重点课题(KJ2018ZD021)。

摘　　要：喉癌是头颈部第二大常见的恶性肿瘤。喉鳞状细胞癌因为早期不易诊断和容易淋巴结转移等特性,其5年生存率较低,从66%下降到63%左右。有效的生物标志物鉴定将有助于喉癌的早期诊断、早期治疗、疾病监测和预后判断。本文主要阐述了近年来与喉癌相关生物标志物的研究进展,包括基因、基质金属蛋白酶、细胞因子、非编码RNA和外泌体五个方面。Laryngeal cancer is the second most common malignant tumor of the head and neck.Laryngeal squamous cell carcinoma is difficult to diagnose early and is prone to lymph node metastasis.In the past 40 years,its 5-year survival rate has dropped from 66%to about 63%.Effective biomarkers will help the early diagnosis,early treatment,disease monitoring and prognosis judgment of laryngeal cancer.This article mainly describes the research progress of biomarkers related to laryngeal cancer in recent years,including five aspects:genes,matrix metalloproteinases,cytokines,non-coding RNA and exosomes.

关 键 词：喉鳞状细胞癌 标志物 MIRNA lncRNA 

分 类 号：R739.65[医药卫生—肿瘤]