5%阿维菌素可湿性粉剂的制备及表征  

Preparation and Characterization of Avermectin 5% Wettable Powder

作　　者：李梓泳 陈龙 岑骏铖 周红军[1] 周新华[1,2] LI Zi-yong;CHEN Long;CEN Jun-cheng;ZHOU Hong-jun;ZHOU Xin-hua(Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution,School of Chemistry and Chemical Engineering,Innovative Institute for Plant Health,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China;Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Maoming 525000,Guangdong,China)

机构地区：[1]仲恺农业工程学院植物健康创新研究院,化学化工学院,广东省普通高校农用绿色精细化学品重点实验室,广州510225 [2]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

出　　处：《农药》2021年第10期715-719,734,共6页Agrochemicals

基　　金：广东省农业产业技术体系共性关键技术(农业纳米)创新团队(2019KJ140);广东省教育厅农用绿色精细化学品科技创新团队(2018KCXTD015);广州市科技计划(201903010011)。

摘　　要：[目的]制备一种分散性好、悬浮率高、持效期长的阿维菌素可湿性粉剂。[方法]以聚甲基丙烯酸甲酯接枝羧甲基纤维素钠(CMC-g-PMMA)为载体,负载阿维菌素。[结果]可湿性粉剂再分散于水中呈现为平均粒径约为115 nm的球体;悬浮液的粒径和PDI小,分散性好,Zeta电位绝对值大于50 mV,有利于体系的稳定贮存;CMC-g-PMMA提高了AVM的抗紫外性能,AVM原药在经过60 min的强光照后,有效成分仅剩余11%,而被封装于CMC-g-PMMA中的AVM仍有25%;药物释放符合First-order和Logistic模型。[结论]这种新型的阿维菌素可湿性粉剂分散性好、持效期长,有望为提高农药有效利用率做出贡献。[Aims] The study aims to prepare a wettable avermectin powder with good dispersibility, high suspension rate and long duration of efficacy. [Methods] Using sodium carboxymethyl cellulose grafted from methyl methacrylate(CMC-g-PMMA) as the carrier, avermectin was supported. [Results] The particle size and PDI of the suspension were small,the dispersion was good, and the absolute value of Zeta potential was greater than 50 mV, which was contribute to the stable storage of the system. CMC-g-PMMA improved the ultraviolet resistance of AVM. After 60 minutes of intense illumination, only 11% of AVM remained, while 25% of the AVM encapsulated in CMC-g-PMMA remained. Drug release was consistent with First-Order and Logistic models. [Conclusions] This new type of Avermectin wettable powder has good dispersibility and long duration, which is expected to contribute to improving the effective utilization rate of pesticides.

关 键 词：阿维菌素 可湿性粉剂 分散性 喷雾干燥 缓释 

分 类 号：TQ450.6[化学工程—农药化工]