钴催化2-芳基吲哚氧化去芳构化及与烯酰胺[3+2]环化反应  

Cobalt-Catalyzed Aerobic Oxidative Dearomatization of 2-Aryl Indoles and in situ[3+2]Annulation with Enamides

作　　者：黄音君 李金山 李珅[1] 马军安[1,2] Huang Yinjuna;LiJinshana;LiShen;Ma Junan(Tianjin Key Laboratory of Molecular Optoelectronic Sciences,and Collaborative Innovation Center of Chemical Science&Engineering,Department of Chemistry,Tianjin University,Tianjin 300072;Joint School of National University of Singapore and Tianjin University,Fuzhou 350207)

机构地区：[1]天津大学理学院化学系天津市分子光电科学重点实验室天津化学化工协同创新中心,天津300072 [2]天津大学-新加坡国立大学福州联合学院,福州350207

出　　处：《有机化学》2021年第10期4028-4038,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21772142,21961142015);国家重点研发计划(No.2019YFA0905100)资助项目.

摘　　要：在氧气氛围中,以2-芳基吲哚和N-乙酰基烯胺为原料,实现了一锅法快速构建三环吲哚啉稠环骨架化合物.该方法具有原料易得、操作简便、区域和非对映选择性较高以及环境友好等特点.机理研究表明,反应首先发生氧化去芳构化,随后与烯酰胺进行[3+2]环化反应.An one-pot reaction for the rapid construction of tricyclic fused indoline frameworks from 2-aryl indoles and N-acetyl enamides under oxygen atmosphere has been developed.The notable features of this method involve easy availability of starting materials,simple manipulation,good regio-and diastereo-selectivity,as well as environmentally friendly conditions.Mechanistic studies indicated that this reaction proceeds via oxidative dearomatization and subsequent[3+2]annulation with enamides.

关 键 词：钴催化 氧化去芳构化 环化反应 吲哚 烯酰胺 

分 类 号：O621.251[理学—有机化学]