丁苯酞联合胞磷胆碱钠治疗脑卒中后认知功能障碍的临床疗效  

Clinical effect of butylphthalide combined with citicoline sodium on cognitive dysfunction after stroke

作　　者：龚德松 GONG Desong(The First Hospital of Nanping City,Nanping 353000,China)

机构地区：[1]福建省南平市第一医院,353000

出　　处：《临床合理用药杂志》2021年第27期8-10,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨丁苯酞联合胞磷胆碱钠治疗脑卒中后认知功能障碍的临床疗效。方法选取南平市第一医院2019年3月—2020年3月收治的脑卒中后认知功能障碍患者120例,根据患者临床用药方法不同分为对照组和观察组,各60例。对照组采用丁苯酞治疗,观察组采用丁苯酞联合胞磷胆碱钠治疗。比较2组治疗前后神经行为认知状态检测量表(NCSE)评分、美国国立卫生研究院卒中量表(NIHSS)评分、张明园修订的简易智力状态检查量表(MMSE)评分、血清同型半胱氨酸(Hcy)水平,并观察2组不良反应发生情况。结果治疗前2组NCSE评分、NIHSS评分、MMSE评分、血清Hcy水平比较,差异无统计学意义(P>0.05);治疗后观察组NCSE评分、MMSE评分高于对照组,NIHSS评分、血清Hcy水平低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论苯酞联合胞磷胆碱钠治疗脑卒中后认知功能障碍的临床疗效确切,有利于患者神经功能恢复,减轻认知功能障碍,降低Hcy水平,治疗安全性较高。Objective To explore the clinical effect of butylphthalide combined with citicoline sodium on cognitive dysfunction after stroke.Methods A total of 120 cases of patients with cognitive dysfunction after stroke were selected from March 2019 to March 2020 in the First Hospital of Nanping City,which were divided into control group and observation group,each with 60 cases.The control group was treated with butylphthalide,while the observation group was treated with butylphthalide combined with citicoline sodium.NCSE score,NIHSS score,MMSE score and serum Hcy level before and after treatment were compared between the two groups,and the incidence of adverse reactions of the two groups were observed.Results There was no significant difference in NCSE score,NIHSS score,MMSE score and serum Hcy level between the two groups before treatment(P>0.05);after treatment,NCSE score and MMSE score of the observation group were higher than those of the control group,while NIHSS score and serum Hcy level were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with citicoline sodium have an exact clinical effect for cognitive dysfunction after stroke,which can conducive to the recovery of patients’neurological function,reducing cognitive dysfunction and Hcy level,and with high safety.

关 键 词：脑卒中 认知功能障碍 丁苯酞 胞磷胆碱钠 治疗结果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]