血清同型半胱氨酸和血脂水平与进展性缺血性脑卒中患者神经功能相关性分析  

Correlation of homocysteine and blood lipid levels with neurological function in patients with progressive ischemic stroke

作　　者：戴贤勇 陈玮 王燕 俞桂芬 戴加勇 Dai Xianyong;Chen Wei;Wang Yan;Yu Guifen;Dai Jiayong(Department of Neurology,Linhai Second People's Hospital,Linhai 317016,Zhejiang Province,China)

机构地区：[1]临海市第二人民医院神经内科,浙江省317016

出　　处：《中国基层医药》2021年第10期1521-1524,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省台州市科技计划社会发展类一般项目(2017A33616)。

摘　　要：目的探讨血清同型半胱氨酸(Hcy)和血脂水平与进展性缺血性脑卒中(PIS)患者神经功能相关性。方法选择临海市第二人民医院于2018年6月至2020年6月收治的缺血性脑卒中患者400例作为研究对象,其中进展组126例与无进展组274例。采用酶联免疫吸附法测定Hcy水平,采用生化分析仪测定高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(LDL-C)和胆固醇(TC)。观察两组血清Hcy、血脂和美国国立卫生研究院卒中量表(NIHSS)评分变化,且分析Hcy和血脂与美国国立卫生研究院卒中量表(NIHSS)评分相关性。结果进展组血清Hcy水平[(28.39±4.36)μmol/L]高于无进展组[(20.17±3.24)μmol/L](t=18.894,P<0.05)。进展组血清LDL-C[(3.29±0.45)mmol/L]、TG[(2.08±0.34)mmol/L]和TC[(4.82±0.79)mmol/L]均高于无进展组[(2.48±0.37)mmol/L、(1.56±0.29)mmol/L和(4.08±0.43)mmol/L],而血清HDL-C[(1.03±0.13)mmol/L]低于无进展组[(1.19±0.14)mmol/L],差异均有统计学意义(t=17.644、14.859、9.860、11.158,均P<0.05)。进展组NIHSS评分[(21.72±4.35)分]高于无进展组[(15.52±2.89)分](t=14.582,P<0.05)。Hcy、LDL-C、TC和TG与NIHSS评分呈线性正相关(r=0.846、0.724、0.718、0.765,均P<0.05),而HDL-C与NIHSS评分呈线性负相关(r=-0.710,P<0.05)。结论PIS患者血清Hcy水平升高,血脂明显异常,且Hcy和血脂与神经功能具有明显相关性。Objective To correlate homocysteine(Hcy)and blood lipid levels with neurological function in patients with progressive ischemic stroke.Methods A total of 400 patients with ischemic stroke who received treatment between June 2018 and June 2020 in Linhai Second People's Hospital were included in this study.Progressive ischemic stroke(n=126)and non-progressive ischemic stroke(n=274)groups were designated.Hcy level was determined by enzyme-linked immunosorbent assay.High-density lipoprotein cholesterol,triacylglycerol,low-density lipoprotein cholesterol and cholesterol levels were measured using a biochemical analyzer.Hcy and blood lipid levels as well as National Institute Health of Stroke Scale(NIHSS)score were determined in each group.Hcy and blood lipid levels were correlated with NIHSS score.Results Hcy level in the progressive ischemic stroke group was significantly higher than that in the non-progressive ischemic stroke group[(28.39±4.36)μmol/L vs.(20.17±3.24)μmol/L,t=18.894,P<0.05].Low-density lipoprotein cholesterol,triacylglycerol and TC levels in the progressive ischemic stroke group were(3.29±0.45)mmol/L,(2.08±0.34)mmol/L and(4.82±0.79)mmol/L,respectively,which were significantly higher than those in the non-progressive ischemic stroke group[(2.48±0.37)mmol/L,(1.56±0.29)mmol/L and(4.08±0.43)mmol/L,t=17.644,14.859,9.860,P<0.05].High-density lipoprotein cholesterol level in the progressive ischemic stroke group was significantly lower than that in the non-progressive ischemic stroke group[(1.03±0.13)mmol/L vs.(1.19±0.14)mmol/L,t=11.158,P<0.05].NIHSS score in the progressive ischemic stroke group was significantly higher than that in the non-progressive ischemic stroke group[(21.72±4.35)points vs.(15.52±2.89)points,t=14.582,P<0.05].Hcy,low-density lipoprotein cholesterol,cholesterol and triacylglycerol levels were linearly and positively correlated with NIHSS score(r=0.846,0.724,0.718,0.765,all P<0.05),while igh-density lipoprotein cholesterol level was linearly and negatively correlated with N

关 键 词：卒中 脑缺血 半胱氨酸 脂蛋白类 HDL 脂蛋白类 LDL 甘油三酯类 胆固醇 

分 类 号：R743.3[医药卫生—神经病学与精神病学]