痛风饮联合秋水仙碱治疗急性痛风性关节炎临床研究  

Clinical Study on Tongfeng Yin Combined with Colchicine for Acute Gouty Arthritis

作　　者：高虎方 朱广伟[1] 卢豪 陈文勇 卫鹏斌 曹佳 陈志刚 GAO Hufang;ZHU Guangwei;LU Hao;CHEN Wenyong;WEI Pengbin;CAO Jia;CHEN Zhigang

机构地区：[1]三门峡市中心医院关节外科,河南三门峡472000

出　　处：《新中医》2021年第18期99-102,共4页New Chinese Medicine

摘　　要：目的:观察痛风饮联合秋水仙碱治疗急性痛风性关节炎(AGA)的临床疗效。方法:选取163例AGA患者,根据单盲法随机分为痛风饮组82例和对照组81例。痛风饮组给予痛风饮联合秋水仙碱治疗,对照组仅给予秋水仙碱治疗,2组均持续治疗1周。比较2组治疗前后中医证候评分,黄嘌呤氧化酶(XOD)、血尿酸(BUA)水平及血清白细胞介素(IL)-1β、IL-6、IL-8水平;比较2组临床疗效及不良反应。结果:治疗后,2组关节疼痛、关节肿胀、心烦不安、发热口渴、小便黄评分均较治疗前降低(P<0.05),痛风饮组上述5项中医证候评分均低于对照组(P<0.05)。治疗后,2组BUA、XOD水平及血清IL-1β、IL-6、IL-8水平均较治疗前降低(P<0.05),痛风饮组BUA、XOD水平及血清IL-1β、IL-6、IL-8水平均低于对照组(P<0.05)。痛风饮组总有效率为91.46%,对照组总有效率为77.78%,2组比较,差异有统计学意义(P<0.05)。治疗期间,2组均未发生严重不良反应。结论:痛风饮联合秋水仙碱治疗AGA可提高临床疗效,有效缓解患者的临床症状,降低其BUA、XOD水平,减轻炎症反应,且安全性高。Objective:To observe the clinical effect of Tongfeng yin combined with colchicine on acute gouty arthritis(AGA).Methods:A total of 163 AGA patients were selected and randomly divided into the Tongfeng yin group(82 cases)and the control group(81 cases)according to single blind method.The Tongfeng yin group was treated with Tongfeng yin combined with colchicine,while the control group was treated with colchicine only.Both groups were treated for one week.The Chinese medicine syndrome scores,the levels of xanthine oxidase(XOD),blood uric acid(BUA)and the levels of serum interleukin(IL)-1β,IL-6 and IL-8 were compared between the two groups before and after treatment.Clinical effect and adverse reactions were compared between the two groups.Results:After treatment,the scores of joint pain,joint swelling,vexation,fever and thirst,and yellow urine were all decreased in both groups when compared with those before treatment(P<0.05);the above five scores in the Tongfeng yin group were lower than those in the control group(P<0.05).After treatment,the levels of BUA,XOD and serum IL-1β,IL-6 and IL-8 in both groups were decreased when compared with those before treatment(P<0.05),and the above levels in the Tongfengyin group were lower than those in the control group(P<0.05).The total effective rate was 91.46%in the Tongfeng yin group,and was 77.78%in the control group,the difference being significant(P<0.05).During treatment,no serious adverse reactions occurred in both groups.Conclusion:The therapy of Tongfeng yin combined with colchicine in the treatment of AGA can improve the clinical effect,alleviate the clinical symptoms effectively,reduce the levels of BUA and XOD,and alleviate the inflammatory response,with high safety.

关 键 词：急性痛风性关节炎 痛风饮 秋水仙碱 中医证候 黄嘌呤氧化酶 血尿酸 炎症因子 

分 类 号：R589.7[医药卫生—内分泌]