MICB/NKG2D信号通路在免疫逃逸中的研究进展  

Progress of MICB/NKG2D signaling pathway in immune escape

作　　者：魏昂(综述) 王天有[1] 张蕊[1] 李志刚(审校)[2] Wei Ang;Wang Tianyou;Zhang Rui;Li Zhigang(Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Disease in Children,Ministry of Education Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Hematologic Disease Laboratory,Hematology Center,Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in Children,Ministry of Education Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院血液病中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室,100045 [2]国家儿童医学中心首都医科大学附属北京儿童医院血液病中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室北京市儿科研究所血液疾病研究室,100045

出　　处：《国际儿科学杂志》2021年第9期584-588,共5页International Journal of Pediatrics

基　　金：国家科技重大专项(2017ZX09304029001);北京市自然科学基金(7214226);北京市教育委员会科技发展计划一般项目(KM202110025011)。

摘　　要：自然杀伤细胞2族成员D(natural killer group 2 member D,NKG2D)是由NK细胞表达的一种免疫受体,可识别靶细胞表面上的人类主要组织相容性复合体Ⅰ类多肽相关序列(major histocompatibility complex Class I polypetide-related chain,MIC)A/B。NKG2D与MICA/B的相互作用,在病毒感染和癌症的免疫监视中发挥重要作用。该文通过膜结合型MICB下调、分泌型MICB增多及MICB基因多态性三部分对MICB/NKG2D信号通路在免疫逃逸中的研究进展进行综述。Natural killer group 2 member D(NKG2D)is an immune receptor expressed by NK cells that recognizes the human major histocompatibility complex class I polypetide-related chain(MIC)A/B on the cell surface.The interaction between NKG2D and MICA/B plays an important role in the immunosurveillance of viruses infection and cancers.In this article,we review the research progress of the MICB/NKG2D signaling pathway in immune escape including three parts:down-regulation of membrane-bound MICB,increase of secretory MICB,and polymorphism of MICB genes.

关 键 词：主要组织相容性复合体Ⅰ类多肽相关序列 自然杀伤细胞2族成员D 免疫逃逸 多态性 

分 类 号：R73[医药卫生—肿瘤]