无创指标对原发性胆汁性肝硬化食管胃底静脉曲张的预测  

The Prediction of Non-invasive Indicators for the Esophageal-gastro Varices in Patients With Primary Biliary Cirrhosis

作　　者：朱静菲[1] 郑立明[1] ZHU Jingfei;ZHENG Liming(Laboratory Department,Changzhou Third People's Hospital,Changzhou Jiangsu 213001,China)

机构地区：[1]常州市第三人民医院检验科,江苏常州213001

出　　处：《中国继续医学教育》2021年第30期118-122,共5页China Continuing Medical Education

摘　　要：目的探讨临床常见血清学指标对原发性胆汁性肝硬化患者食管胃底静脉曲张的预测价值。方法收集2018年1月-2020年5月期间在江苏省常州三院住院的PBC患者共70例(其中伴食管胃底静脉曲张患者21例,无食管胃底静脉曲张患者49例)的临床资料及住院常规检查项目。综合统计分析各指标,评估PBC患者发生食管胃底静脉曲张的风险。结果单因素分析显示ALB、PLT、TBil、RDW、PT、INR、NVP积分、Mayo积分、ALBI积分在两组间差异有统计学意义(P<0.05),但多因素Logistic回归分析显示均差异无统计学意义(P>0.05);ALBI积分、Mayo积分、NVP积分、INR、RDW,随着Child-Pugh评分分级增加而增高;ROC曲线显示,ALBI积分、Mayo积分、NVP积分、INR、RDW对PBC患者食管胃底静脉曲张具有较好的预测作用,其曲线下面积分别为0.857,0.831,0.804,0.753,0.848。结论ALBI积分、NVP积分、Mayo风险评分、INR、RDW对预测PBC患者食管胃底静脉曲张的发生均具有重要的临床预测价值。Objective To explore the value of non-invasive serum indicators in predicting the esophageal-gastro varices in patients with primary biliary cirrhosis.Methods A total of 70 patients with primary biliary cirrhosis hospitalized in changzhou third Hospital from January 2018 to may 2020 were enrolled,including 21 patients with esophageal-gastro varices and 49 patients without esophageal-gastro varices.The risk of esophageal-gastro varices in patients was evaluated according to the clinical characteristics and laboratory examination results.Results Univariate analysis showed that there were significant differences in ALB,PLT,TBil,RDW,PT,INR,NVP,Mayo and ALBI scores between two groups(P<0.05),but Multivariate Logistic regression analysis showed that there was no differences.The ALBI score,Mayo score,NVP score,INR and RDW increased with the Child-Pugh score.ROC curve also showed that ALBI score,Mayo score,NVP score,INR and RDW could predictive for esophageal-gastro varices in patients with primary biliary cirrhosis,and their AUC areas were 0.857,0.831,0.804,0.753,0.848,respectively.Conclusion ALBI score,NVP score,Mayo risk score,INR and RDW have important clinical value in predicting the occurrence of esophageal-gastro varices in patients with primary biliary cirrhosis.

关 键 词：无创血清学指标 原发性胆汁性肝硬化 食管胃底静脉曲张 临床预测价值 肝硬化 常规项目 

分 类 号：R575[医药卫生—消化系统]