儿童眶周毛母质瘤112例临床及病理学分析  

Clinical and pathological analysis of 112 cases of periorbital pilomatricoma in children

作　　者：任艳红[1] 史彩平[1] 朱慧慧[1] 顾伟忠[1] Ren Yanhong;Shi Caiping;Zhu Huihui;Gu Weizhong(Department of Ophthalmology,The Children s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院眼科国家儿童健康与疾病临床医学研究中心,杭州310052

出　　处：《眼科》2021年第5期379-383,共5页Ophthalmology in China

摘　　要：目的探讨儿童眶周毛母质瘤的临床及病理特点。设计回顾性病例系列。研究对象2014年1月到2020年6月在浙江大学医学院附属儿童医院行手术治疗的眶周毛母质瘤患儿112例。方法回顾分析患儿的临床及病理资料,包括年龄、性别、发病部位、超声及病理学特点等。主要指标患儿年龄、性别、发病部位、肿瘤超声及病理学特点。结果112例中手术时年龄7个月到11岁2个月(中位数3岁8个月)。男性54例。发病部位眉弓74例(66.1%)、上睑29例(25.9%)、下脸7例(6.2%)、眼睑内眦部2例(1.8%)。57例术前行超声检查,38例(66.8%)瘤体内可见钙化,38例(66.8%)瘤体内或周边可见血流信号。组织病理学检查均可见影细胞及嗜碱性细胞,其中91例(81.3%)可见钙化,78例(69.6%)可见多核巨细胞反应。所有病例经手术切除,术后无一例复发或恶变。结论儿童眶周皮下结节应考虑毛母质瘤的可能,超声检查对其诊断有一定价值,早期手术完整切除治疗有效。Objective To explore the clinical and pathological characteristics of periorbital pilomatricoma in children.Design Retrospective case series.Participants 112 children with periorbital pilomatricoma who underwent surgical treatment in Children's Hospital of Zhejiang University School of Medicine from January 2014 to June 2020.Methods The clinical and pathological data of all patients including the age,gender,location of onset,ultrasound and pathological characteristics were reviewed.Main Outcome Measures Children's age,sex,location of onset,ultrasound and pathological characteristics of the tumor.Results 112 cases of children had an operating age of 7 months to 11 years and 2 months,with median operating age of 3 years and 8 months.54 cases were males.74 cases(66.1%)located in the eyebrow,29 cases(25.9%)in the upper eyelid,7 cases(6.2%)in the lower eyelid,and 2 cases(1.8%)in the inner canthus of the eyelid.57 cases underwent preoperative ultrasound examination,38 cases(66.8%)had calcification in the tumor,and 38 cases(66.8%)had blood flow signals in or around the tumor.Histopathological examination showed shadow cells and basophils,of which 91 cases(81.3%)had calcifications.78 cases(69.6%)showed multinucleated giant cell response.All cases were surgically removed,and there was no recurrence or malignant transformation after surgery.Conclusion Children with periorbital subcutaneous nodules should consider the possibility of pilomatricoma.Ultrasonography has a certain diagnosis value for periorbital pilomatricoma.Early surgical complete resection is effective treatment.

关 键 词：眶周 毛母质瘤 儿童 

分 类 号：R739.7[医药卫生—肿瘤]