油樟中倍半萜化合物及其衍生物的合成与生物活性研究  

Synthesis and Biological Activity of Sesquiterpenoids from Cinnamomum longepaniculatum and Its Derivatives

作　　者：胡文杰[1] 殷帅文[1] 戴彩华 周升团[1] HU Wen-jie*;YIN Shuai-wen;DAI Cai-hua;ZHOU Sheng-tuan(College of Life Science,Jinggangshan University,Ji’an,Jiangxi 343009,China;Faculty of Medicine,Jinggangshan University,Ji’an,Jiangxi 343009,China)

机构地区：[1]井冈山大学生命科学学院,江西吉安343009 [2]井冈山大学医学部,江西吉安343009

出　　处：《浙江化工》2021年第10期12-16,共5页Zhejiang Chemical Industry

基　　金：江西省自然科学基金项目(20181BAB204014);江西省教育厅科技计划项目(GJJ170641);国家自然科学基金项目(32160089)。

摘　　要：为了寻找具有抑百合鳞茎腐烂病菌活性及抑菌活性的新型化合物。本试验以百合鳞茎腐烂病菌为研究对象,分别采用菌丝生长速率法和盆栽法,测定了倍半萜化合物芳姜黄酮及其衍生物对该病菌的活性。结果表明,芳姜黄酮及其衍生物表现出较好的抑百合鳞茎腐烂病菌活性,尤其是化合物3-甲基-N-(1-(4-氯苯基)乙基)-2-丁烯酰胺和3-甲基-N-(1-(4-甲基苯基)乙基)-2-丁烯酰胺,抑菌率达90%以上,同时这2种化合物在盆栽试验中,防治效果也均达到了84%以上,因此该化合物的结构改造或修饰为创制新型杀菌剂提供了重要依据,具有较好的研究价值。The purpose of this study was to search for new compounds with antifungal activity and antifungal activity against Lily bulb rot disease.In this study,the activity of ar-turmerone and its derivatives against Lily bulb rot disease was determined by mycelial growth rate method and in vivo pot culture method.The results showed that ar-turmerone and its derivatives exhibited good antibacterial activity against Lily bulb rot disease,especially compounds 3-methyl-N-(1-(4-chlorophenyl)ethyl)-2-butenamide and 3-methyl-N-(1-(4-methylphenyl)ethyl)-2-butenamide,with antibacterial rate of over 90%.At the same time,the control effect of these two compounds in living pot experiments also reached more than 84%,Therefore,the structural modification and modification of these compounds provide an important basis for the creation of new fungicides and have good research value.

关 键 词：油樟 倍半萜成分 有机合成 抑菌活性 构效 

分 类 号：TQ455[化学工程—农药化工]