载有5-FU的聚乙烯醇高聚物的合成  

The Synthesis of Polymers of Polyvinyl Alcohol Linking 5-FU

作　　者：周朝华[1] 张炜[1] Zhou Chaohua;Zhang Wei(Department of Chemistry,Lanzhou University,Lanzhou)

机构地区：[1]兰州大学化学系

出　　处：《高等学校化学学报》1987年第8期758-760,共3页Chemical Journal of Chinese Universities

摘　　要：5-FU具有抗瘤谱广、有效率高的特点,但在体内代谢快、有效期短,而且毒副作用较严重,近年来,人们发现将5-FU通过化学键与天然的或合成的高分子相连,可以得到具有潜在活性的高分子抗肿瘤药。它们具有缓解的特点,可以使5-FU长效低毒[1-4]。本文作者首次以下列方法合成了载有5-FU的聚乙烯醇高聚物。By the reactions of three kinds of sodium poly vinyl alcohol of different average molecular weight with 1-(chloroacetyl)-5-fluorouracil(AF)or 1-(2-chloro-propionyl)-5-fluorouracil(PF)in absolute DMSO,six kinds of new polymers were prepared.Meanwhile,the influence of reaction conditions and average molecular weight of polyvinyl alcohol on the new polymers was studied systematically.The structural characteristics of the new polymers were investigated by IR and UV;hydrolysis of the new polymers in various buffer solutions(pH1.5,7.0 and 9.0)was measured by UV,and it was obvious that the new polymers could release out 5-FU.

关 键 词：抗肿瘤药 毒副作用 体内代谢 潜在活性 聚乙烯醇 高聚物 化学键 高分子 

分 类 号：R73[医药卫生—肿瘤]