Access to Polycyclic lndol(en)ines via Base-Catalyzed Intramolecular Dearomatizing 3-Alkenylation of Alkynyl Indoles  

作　　者：Lin Lu Zuoliang Zheng Yongjie Yang Bo Liu Biaolin Yin 

机构地区：[1]Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,Guangdong 510640,China [2]The Second Clinical Medical College,and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China [3]Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Journal of Chemistry》2021年第8期2207-2212,共6页中国化学（英文版）

基　　金：This work was supported by grants from the National Program on Key Research Project(No.2016YFA0602900);the National Natural Science Foundation of China(Nos.21572068 and 21871094);the Guangdong Natural Science Foundation(No.2017A030312005);the Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine[(2014)NO.32];the Special Foundation of Guangzhou Key Laboratory(No.202002010004).

摘　　要：Polycyclic in doli nes and in dole nines were synthesized via base-catalyzed in tramolecular dearomatizi ng 3-alke nylation reacti ons of al-kynyl in doles 1 at room temperature.The base enhan ced the nu cleophilicity of the carb on at the 3-position of the indole moiety,facilitating an exclusive S-exo-dig cyclization reaction with the alkyne to form spiroindolenines2.

关 键 词：DEAROMATIZATION Domino reaction Alkynyl indole Synthetic method Cyclization 

分 类 号：O62[理学—有机化学]