载有5-氟脲嘧啶高分子药物的合成、结构及性能的研究  

Synthesis,Structure and Behavior of Polymeric Drugs Covalently Linked 5-Fluorouracil

作　　者：周朝华[1] 杨福顺 Zhou Chaohua;Yang Fushun(Department of Chemistry,Lanzhou University,Lanzhou)

机构地区：[1]兰州大学化学系 [2]山东海洋学院化学系

出　　处：《高等学校化学学报》1987年第1期87-92,共6页Chemical Journal of Chinese Universities

摘　　要：用可溶性淀粉或羧甲基纤维素作载体,合成了侧链连有5-氟脲嘧啶的四个系列的高分子载体药物;用分子筛作催化剂合成了两种新的5-氟脲嘧啶衍生物,利用IR、^(1)H NMR和质谱确定了它们的结构;研究了高分子药物含氮量随反应条件的变化规律及对其特性粘度的影响;并模拟生理条件在不同pH的缓冲溶液中对5-氟脲嘧啶的水解释放率进行了系统考查,对个别淀粉衍生物进行了生物活性测定。Four scries of macromolocular drugs covalently.linked 5-fluorouracil(5-FU)are synthesized by the use of soluble starch and carboxylmcthylccllulose as carries,and two new 5-FUderivatives by the use of molecular sieve as catalyst.Their structure arc determined by R,1HNMR and mass spectra.The changes for the nitrogen content of polymeric drugs with reactions and the influence of the Ncontent on their limiting viscosily arc studied.The hydrolysis delivery of 5-FUfrom starch and carboxymethyl-cellulose derivatives in various of buffer arc researched by moulding physiologicaly acid-alkali enviroment.In addition,antican-car activity(in vivo and in vitro)of some starch derivative has been prelimina-ryly observed.

关 键 词：高分子药物 淀粉衍生物 羧甲基纤维素 特性粘度 生理条件 高分子载体药物 可溶性淀粉 催化剂合成 

分 类 号：O62[理学—有机化学]