125I粒子植入对兔VX2实体瘤周围组织损伤的评价  

Evaluation of the damage to the surrounding tissues of rabbit VX2 solid tumor by 125I particles implantation

作　　者：姚永熠 王正 王娟 Yao Yongyi;Wang Zheng;Wang Juan(Department of Nuclear Medicine,Jincheng General Hospital,Jincheng 048006,China)

机构地区：[1]山西省晋城大医院核医学科,048006

出　　处：《中国实用医刊》2021年第16期23-26,共4页Chinese Journal of Practical Medicine

摘　　要：目的评价125I粒子植入对兔VX2(ShPoe病毒诱导的兔乳头状鳞癌)实体瘤周围组织损伤情况。方法将VX2瘤株种植于新西兰大耳白兔双后腿肌肉内制备肿瘤模型30只,10 d后行首次PET/CT显像及植入不同初始活度125I粒子,左后腿植入低活度0.4 mCi(0.4 mCi组),右后腿植入高活度0.7 mCi(0.7 mCi组)。植入后不同时间点(72 h、2周、4周)行PET/CT显像,并取距离病灶边缘2 cm内的正常肌肉组织给予HE染色观察组织学变化,分析标准摄取值(SUV)与炎症反应的相关性。结果不同初始活度125I粒子植入治疗兔VX2肿瘤与治疗前比较周围正常组织SUV值逐渐增高。治疗后2周炎症反应达高峰,0.7 mCi组治疗后2周SUV值与炎症反应呈正相关(r=0.684,P<0.05),治疗后72 h、4周两组SUV值与炎症反应未见相关性(r=-0.091、-0.073、0.012、-0.170、0.250,P>0.05)。结论不同活度125I粒子对周围正常组织无明显不良反应,0.7 mCi活度对周围组织损伤较0.4 mCi活度略重,总体安全性高。Objective To evaluate the damage to the surrounding tissues of rabbit VX2(a squamous cell carcinoma derived from rabbit papilloma induced by ShPoe virus)solid tumor by 125I particles implantation.Methods The VX2 tumor strain was planted in the muscles of the hind legs of New Zealand white rabbits to prepare 30 tumor models,the first PET/CT imaging and implantation of 125I particles with different initial activities were performed after 10 days.The left hind leg was implanted with a low activity of 0.4 mCi(0.4 mCi group),and the right hind leg was implanted with a high activity of 0.7 mCi(0.7 mCi group).PET/CT imaging was performed at different time points(72 h,2 weeks,4 weeks)after implantation,and normal muscle tissue within 2 cm from the edge of the lesion was taken for HE staining to observe histopathology changes.The correlation between standard uptake value(SUV)and inflammation was analyzed.Results The SUV value of rabbit VX2 tumor treated with 125I particles implantation with different initial activity increased gradually compared with that before treatment.The inflammatory response reached a peak 2 weeks after treatment,and the SUV value of the 0.7 mCi group was positively correlated with the inflammatory response 2 weeks after treatment(r=0.684,P<0.05).At 72 hours and 4 weeks after treatment,there was no correlation between SUV values and inflammation in the two groups(r=-0.091,-0.073,0.012,-0.170,0.250,P>0.05).Conclusions The 125I particles with different activity had no obvious adverse reaction to the surrounding normal tissue,0.7 mCi group had slightly more damage to the surrounding tissue than 0.4 mCi group,and the overall safety is higher.

关 键 词：鳞癌 兔VX2移植瘤 125I粒子植入 正电子发射计算机断层显像 标准摄取值 

分 类 号：R73-3[医药卫生—肿瘤]