基于核因子κB信号通路的中医方药防治认知障碍机制的研究进展  

Advances in the Mechanism of Chinese Medicine Targeting NF-κB Signaling Pathway in the Prevention and Treatment of Cognitive Impairment

作　　者：罗萌 高静 段昭远 刘承梅[1,2] 李瑞青[1,2] 苏凯奇 陈卓[2] 冯晓东[1,2] LUO Meng;GAO Jing;DUAN Zhaoyuan;LIU Chengmei;LI Ruiqing;SU Kaiqi;CHEN Zhuo;FENG Xiaodong(Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,河南省郑州市450000 [2]河南中医药大学第一附属医院,河南省郑州市450000

出　　处：《中国全科医学》2021年第36期4640-4647,共8页Chinese General Practice

基　　金：国家自然科学基金面上项目(81574042);河南省中医管理局国家中医临床研究基地科研专项(重点项目)(2018JDZX011);河南省科技攻关计划(202102310167)。

摘　　要：认知障碍是指在注意力、学习记忆能力、执行功能、语言功能、知觉运动功能和社会认知中存在一个或多个方面的功能障碍。随着全球老龄化进程的加速,认知障碍将在全球范围内流行,且目前尚无特效药。核因子κB(NF-κB)信号通路可以调控炎症、凋亡、氧化应激等过程,在认知障碍病程中广泛存在及激活。目前许多以调控NF-κB信号途径为目标的实验方法正在从分子生物学角度为防治认知障碍探索一种新途径。为此,本文对中药复方、中药单味药及其提取物通过调控NF-κB信号通路防治认知障碍的文献进行综述,旨在为NF-κB信号通路能否作为中药发挥作用的靶点提供理论依据。Cognitive impairment(CI)refers to impaired attentiveness,learning and memory ability,executive function,language ability,perceptual and motor functions,or social cognition.There is no effective pharmaceutical treatment for CI although it will be prevalent worldwide as the global aging accelerates.The nuclear factor-κB(NF-κB)signaling pathway can regulate inflammation,apoptosis,oxidative stress and other processes,and has been widely present and activated in the development of CI.Many experiments are underway to try to explore a new molecular biology approach to the prevention and treatment of CI based on regulating the NF-κB signaling pathway.We reviewed the use of single,compound preparations of Chinese medicine,and Chinese herbal extracts to prevent and treat CI via regulating NF-κB signaling pathway,providing evidence for studies regarding the use of Chinese medicine for CI with this pathway as a treatment target.

关 键 词：认知障碍 转录因子 NF-ΚB信号通路 中草药 中药方剂学 

分 类 号：R741[医药卫生—神经病学与精神病学]