慢性疾病症状在高雄激素化动物模型的研究进展  

Research progress of chronic diseases in hyperandrogenized animal models

作　　者：孙立峰 全军民 SUN Li-feng;QUAN Jun-min(State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055,China)

机构地区：[1]北京大学深圳研究生院,化学生物学与生物技术学院,肿瘤化学基因组学国家重点实验室,广东深圳518055

出　　处：《中国药理学通报》2021年第11期1481-1486,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No21521003,81373326,21290183)。

摘　　要：慢性疾病是指非传染性、病程长且病情迁延不愈的一类疾病。其常见症状包括胰岛素抵抗、脂代谢紊乱、慢性炎症等。脱氢表雄酮(dehydroepiandrosterone,DHEA)和双氢睾酮(dihydrotestosterone,DHT)持续刺激可以导致大、小鼠表现多种症状。这类模型具有肥胖,卵巢发育异常,血管内皮功能紊乱,慢性炎症等症状。除了以上症状,DHT处理动物模型还适用于胰岛素抵抗、脂代谢紊乱、生物节律紊乱等症状的研究。而DHEA处理动物模型还适用于卵巢应激综合征等的研究。虽然DHEA不适用于高血脂等代谢疾病的研究,但是DHEA加高脂饮食处理动物则可以研究相关问题。基于此前的研究可以展望,利用这类模型,在子宫内膜的发育、卵巢细胞活性、炎症反应的调节、动脉粥样硬化、生物节律紊乱等问题能够得到新的发现。Chronic disease is defined as a persistent,recurrent illness with long course.Common symptoms include insulin resistance,dyslipidemia,chronic inflammation,and so on.It is well known that chronic dehydroepiandrosterone(DHEA)or dihydrotestosterone(DHT)exposure induces symptoms in rats or mice.These animals possess characteristics of obesity,ovarian dysfunction,vascular endothelial dysfunction,inflammation,and so on.In addition,DHT-treated animals have been used to explore insulin resistance,dyslipidemia,and biorhythm disorder.DHEA-treated animals were fit to detect ovarian stress.Although DHEA-treated animals does not apply to studies of metabolic diseases such as hyperlipidemia,DHEA-treated animals under high fat diet represent the related phenotypes.Based on the previous research,it can be predicted that new achievements will be made in endometrial development,ovarian cell function,inflammation modulation,atherosclerotic,and biorhythm disorder by using these hyperandrogenic animal models.

关 键 词：雄激素 多囊卵巢综合征 肥胖 糖代谢 脂代谢 心血管 炎症 生物节律 

分 类 号：R-332[医药卫生] R347.911