类风湿关节炎实验性动物模型研究进展  

Advances on experimental models of rheumatoid arthritis

作　　者：李利青[1,2] 张逢 彭馥芝 罗前颖[1] 李鑫[2] 刘良[2,3] LI Li-qing;ZHANG Feng;PENG Fu-zhi;LUO Qian-ying;LI Xin;LIU Liang(Guangxi Provincial Key Laboratory of Preventive and Therapeutic Research in Prevalent Diseases in West Guangxi, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China;Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;State Key Laboratory of Quality Research in Chinese Medicine, Macao University of Science and Technology, Macao 999078, China)

机构地区：[1]右江民族医学院桂西高发病防治重点实验室,广西百色533000 [2]湖南中医药大学中药粉体与创新药物省部共建国家重点实验室(培育基地),湖南长沙410208 [3]澳门科技大学中药质量研究国家重点实验室,中国澳门999078

出　　处：《中国药理学通报》2021年第11期1492-1497,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No81803993);湖南省科技创新重大项目(No2020SK1020);湖南省“刘良院士专家工作站”资助项目(No湘科协通〔2020〕34号);广西自然科学基金项目(No2019GXNSFBA245042,2020GXNSFAA297053)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一种病因不明的慢性自身免疫性疾病,不仅影响关节的活动和健康,还累及全身多个组织器官。RA目前尚无特效药治疗,是国内外研究的热点和难点,构建与人类RA相似度高的动物模型对研究该疾病的发病机制及药物治疗至关重要。该文就目前常用RA动物模型的构建方法、发病机制及病理特征等展开论述,以期为合理选择实验动物模型作为RA的基础研究与药物筛选提供依据和参考。Rheumatoid arthritis(RA)is a chronic immune-mediated synovial disease with unknown aetiology;therefore,it is considered a chronic disease that cannot be cured.RA is caused by a complex interaction between genetic and environmental factors.As such long-standing efforts have been made for better understanding of disease pathogenesis and the development of new classes of therapeutics,the continuing elucidation of pathogenic events underlying RA mostly relies on animal model studies.Individually animal models allow molecular and spatiotemporal dissection of various pathological processes of RA development.We have herein comprehensively discussed different animal models in induction methods,pathogenesis,pathological events and disease characteristics,hoping to provide the basis and reference for the rational selection of experimental animal models for the basic research and drug screening of RA.

关 键 词：自身免疫性疾病 类风湿关节炎 动物模型 发病机制 病理特征 药物筛选 

分 类 号：R-332[医药卫生] R363-332