肿瘤样钙质沉着症32例临床和病理分析  

Clinical and pathological analysis of 32 cases of tumoral calcinosis

作　　者：左庆瑶[1] 刘宝岳[2] 王红[1] 李淳[3] 牛晓辉[4] 邓微[1] Zuo Qingyao;Liu Baoyue;Wang Hong;Li Chun;Niu Xiaohui;Deng Wei(Department of Endocrinology and Metabolism,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Pathology,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Hand Surgery,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Orthopaedic Oncology,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院内分泌科,北京100035 [2]北京积水潭医院病理科,北京100035 [3]北京积水潭医院手外科,北京100035 [4]北京积水潭医院骨肿瘤科,北京100035

出　　处：《中国医刊》2021年第11期1211-1214,共4页Chinese Journal of Medicine

基　　金：国家重点研发计划(2020YFC2004900)。

摘　　要：目的肿瘤样钙质沉着症(tumoral calcinosis,TC)是以皮下组织异位钙化为主要表现的骨代谢疾病。本研究分析了TC的临床和病理特征,旨在为本病的早期诊治提供依据。方法回顾性分析2012年1月至2020年12月于北京积水潭医院住院治疗的32例TC患者的临床和病理特征。根据病因分为原发性TC组和继发性TC组;根据血磷水平分为高血磷型组和正常血磷型组。结果患者男女比例1∶1.9,平均年龄(47.8±18.0)岁,病程为2.0(0.8,3.8)年。肿物大小为1.3(1.0,2.0)cm,20处(62.5%)病灶在小关节周围(手和腕),8处(25.0%)在大关节周围(肩、髋、膝、肘和足)。4例(12.5%)发生骨或关节破坏。原发性TC组和继发性TC组的性别、肿物大小、位置和诱因比较差异无显著性(P>0.05)。高血磷型组的肿物大于正常血磷型组,差异有显著性(P<0.05)。病灶的组织学表现为多结节状病变,结节内有无定形或颗粒状的蓝紫色晶体物质沉积。结论TC患者年龄范围较宽,多见于成年人,病灶的位置多见于小关节,需警惕骨与关节的破坏。Objective Tumoral calcinosis(TC)is a bone metabolic disorder characterized by ectopic calcification in subcutaneous tissue.This study analyzed the clinical and pathological characteristics of TC,aiming to provide evidence for the early diagnosis and treatment of this disease.Method A retrospective analysis was performed in 32 cases of TC from January 2012 to December 2020.According to whether there was a cause or not,the cases were divided into primary TC group and secondary TC group.According to the blood phosphorus level,the cases were divided into hyperphosphatemic TC group and normophosphatemic TC group.Result The ratio of male to female patients was 1:1.9 with the mean age of(47.8±18.0)years and median duration of 2.0(0.8,3.8)years,respectively.The median size of the lesion was 1.3(1.0,2.0)cm,20 lesions(62.5%)were around the small joints(hands and wrists),and 8(25.0%)were around the large joints(shoulder,hip,knee,elbow and foot).Bone or joint destruction occurred in 4 cases(12.5%).There was no significant difference between the primary TC group and the secondary TC group in gender,tumor size,location and inducement.The size of the tumor was higher than that of the normal serum phosphorus group(P<0.05).The histology of the lesion showed multi-nodular lesions,with amorphous or granular blue-purple crystal deposits in the nodules.Conclusion The age range of TC is wide,and it is common in adults.The location of the lesion is more common in the small joints,which can cause bone and joint destruction.

关 键 词：肿瘤样钙质沉着症 异位钙化 骨损害 

分 类 号：R736[医药卫生—肿瘤]