四磨汤口服液联合常规疗法治疗新生儿腹胀临床研究  

Clinical Study on Simo Tang Oral Liquid Combined with Conventional Therapy for Neonatal Abdominal Distension

作　　者：王品品[1] 常晶[1] 王广州[1] 黄楠楠 于凤琴[1] WANG Pinpin;CHANG Jing;WANG Guangzhou;HUANG Nannan;YU Fengqin

机构地区：[1]郑州市妇幼保健院新生儿一区,河南郑州450012

出　　处：《新中医》2021年第19期49-52,共4页New Chinese Medicine

摘　　要：目的:观察四磨汤口服液联合常规疗法治疗新生儿腹胀的临床疗效。方法:选取160例新生儿腹胀患儿作为研究对象,按随机数字表法分为观察组及对照组各80例。对照组给予常规疗法,观察组在对照组基础上给予四磨汤口服液治疗,2组均治疗观察2周。比较2组患儿在治疗期间的体质量增长速度,观察2组临床疗效,比较2组治疗前后肠道菌群水平(肠杆菌、乳杆菌)及血清胃动素(MTL)、P物质水平。结果:治疗期间,观察组患儿体质量平均增长速度高于对照组(P<0.05)。观察组临床疗效总有效率为98.8%,对照组为88.8%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组肠杆菌水平均较治疗前降低(P<0.05),乳杆菌水平较治疗前升高(P<0.05);观察组肠杆菌水平低于对照组(P<0.05),乳杆菌水平高于对照组(P<0.05)。治疗后,2组MTL、P物质水平均较治疗前升高(P<0.05),观察组上述2项水平均高于对照组(P<0.05)。结论:四磨汤口服液联合常规疗法治疗新生儿腹胀能促进MTL与P物质的分泌,改善肠道菌群,缓解临床症状,从而促进新生儿体质量增加。Objective: To observe the clinical effect of Simo tang oral liquid combined with conventional therapy on neonatal abdominal distension. Methods:A total of 160 neonates with abdominal distension were selected as the research objects,and divided into observation group and control group by random number table method,80 cases in each group. The control group was given conventional therapy,and the observation group was additionally given Simo tang oral liquid based on the treatment of the control group. Both groups were treated and observed for two weeks. The rate of weight gain in both groups during the treatment was recorded, and the clinical effect was observed. The levels of intestinal flora including enterobacter and lactobacillus, serum motilin(MTL) and substance P were compared between the two groups before and after treatment. Results:During the treatment,the average rate of weight gain in the observation group was higher than that in the control group(P<0.05). The total effective rate was 98.8% in the observation group and 88.8% in the control group,the difference being significant(P<0.05). After treatment, the level of enterobacter in both groups was decreased when compared with that before treatment(P<0.05), and the level of lactobacillus was increased(P<0.05);the level of enterobacter in the observation group was lower than that in the control group(P<0.05),and the level of lactobacillus was higher(P<0.05). After treatment,the levels of serum MTL and substance P in both groups were increased when compared with those before treatment(P<0.05), and the above two levels in the observation group were higher than those in the control group(P<0.05). Conclusion:Simo tang oral liquid combined with conventional therapy in the treatment of neonatal abdominal distension can promote the secretion of MTL and substance P, improve intestinal flora, alleviate clinical symptoms,and promote the weight gain of newborn.

关 键 词：新生儿腹胀 四磨汤 乳杆菌 胃动素 P物质 

分 类 号：R248.4[医药卫生—中医临床基础]