中间入路单侧甲状腺叶全切除术治疗甲状腺单发肿瘤患者的效果及其对血清炎症因子、甲状腺功能的影响  

The effect of unilateral total thyroidectomy by intermediate approach in the treatment of patients with single thyroid tumor and its influence on serum inflammatory factors and thyroid function

作　　者：谢梦博 谌彦军[1] 靳若欣 Xie Meng-bo;Chen Yan-jun;Jin Ruo-xin(Department of Surgery,The Third People's Hospital of Luohe,Luohe 462300,Henan,China;Department of Pediatrics,The Third People's Hospital of Luohe,Luohe 462300,Henan,China)

机构地区：[1]漯河市第三人民医院外科,河南漯河462300 [2]漯河市第三人民医院儿科,河南漯河462300

出　　处：《四川生理科学杂志》2021年第8期1354-1357,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨中间入路单侧甲状腺叶全切除术治疗甲状腺单发肿瘤患者的效果及其对血清炎症因子、甲状腺功能的影响.方法:选取我科2018年7月至2020年9月期间103例甲状腺单发肿瘤患者作为研究对象,按随机数字表法分为对照组和观察组,对照组51例给予外侧入路单侧甲状腺叶全切除术治疗,观察组52例给予中间入路单侧甲状腺叶全切除术治疗,对比两组患者手术指标、血清炎症因子、甲状腺功能、并发症发生情况.结果:观察组的手术时间、切口长度、术后住院时间短于对照组,术中出血量、引流量少于对照组,(P<0.05),治疗后,观察组的白细胞介素(Interleukin,IL)-6、肿瘤坏死因子(Tumor necrosis factor,TNF)-α均低于对照组(P<0.05),治疗后,两组的游离三碘甲状腺原氨酸(Free triiodothyronine,FT3)、游离甲状腺素(Free Thyroxine,FT4)、促甲状腺激素(Thyroid Stimulating Hormone,TSH)水平对比无统计学意义(P>0.05),观察组(7.69%)的并发症发生率低于对照组(21.57%)(P<0.05).结论:两种入路方式对甲状腺单发肿瘤患者的甲状腺功能无明显影响,但中间入路单侧甲状腺叶全切除术所需手术时间较短,切口小、术中出血量较少,且可降低患者术后的炎症反应,有助于缩短康复进程,术后并发症少.Objective:To investigate the effect of unilateral total thyroidectomy with intermediate approach on patients with single thyroid tumor and its effect on serum inflammatory factors and thyroid function.Methods:A total of 103 patients with single thyroid tumor in our department from July 2018 to September 2020 were selected as research subjects,and divided into control group and observation group according to random number table method.Fifty-one patients in the control group were treated with unilateral total thyroidectomy through lateral approach,and 52 patients in the observation group were treated with unilateral total thyroidectomy through intermediate approach.Surgical indicators,serum inflammatory factors,thyroid function and complications were compared between the two groups.Results:The operation time,incision length and postoperative hospital stay in the observation group were shorter than those in the control group,and the intraoperative blood loss and drainage volume were less than those in the control group(P<0.05).After treatment,interleukin-6,Tumor necrosis factor,TNF-α was lower than that of the control group(P<0.05),and the Free triiodothyronine(FT3)and Free Thyroxine(Free Thyroxine),There was no significant difference in the levels of Thyroid Stimulating Hormone(TSH)and FT4(P>0.05),and the incidence of complications in the observation group(7.69%)was lower than that in the control group(21.57%)(P<0.05).Conclusion:The two approaches have no significant effect on thyroid function of patients with single thyroid tumor,but unilateral total thyroidectomy with intermediate approach requires shorter operation time,small incision,less intraoperative blood loss,and can reduce postoperative inflammatory response,help shorten the rehabilitation process,and fewer postoperative complications.

关 键 词：单侧甲状腺叶全切除术 中间入路 外侧入路 甲状腺单发肿瘤 甲状腺功能 血清炎症因子 

分 类 号：R73[医药卫生—肿瘤]