小RNA调控卵泡发育的研究进展  

Advances of the Regulation of microRNAs in Follicular Development

作　　者：孙艳美[1] 王喜艳[1] 吴迪 王雪楠[2] 潘晓燕[1] SUN Yanmei;WANG Xiyan;WU Di;WANG Xuenan;PAN Xiaoyan(Center for Reproductive Medicine,Jilin Medical University,Jilin,Jilin 132013,China;Reproductive Medicine Center of Affiliated Hospital of Jining Medical University,Jining,Shandong 272029,China)

机构地区：[1]吉林医药学院生殖医学研究中心,吉林吉林132013 [2]济宁医学院附属医院生殖科,山东济宁272029

出　　处：《中国医学科学院学报》2021年第5期815-821,共7页Acta Academiae Medicinae Sinicae

基　　金：吉林省科技发展计划项目(20200201132JC);吉林省卫生与健康青年科技骨干培养计划(2018Q047);吉林市科技创新发展计划项目(201831721);吉林省教育厅“十三五”科学技术研究项目(JJKH20191065KJ、JJKH20200454KJ);山东省中医药科技发展计划项目(2019-0463);吉林省大学生创新创业训练计划项目(dc201952、dc201954)。

摘　　要：人们已在卵泡发育的不同阶段和不同细胞中均检测到小RNA(miRNAs)的存在,并在成熟卵泡的卵泡液中也发现外泌体miRNAs。miRNAs不仅参与调控正常的卵泡发育过程,其异常调控也可导致一些卵巢疾病的发生。为进一步系统阐明miRNAs对卵泡发育的调控机制,寻找可以预测卵母细胞发育质量的外泌体miRNAs,本文从颗粒细胞发育、卵母细胞发育和激素合成等方面总结了miRNAs对卵泡发育的调控作用。In recent years,microRNAs(miRNAs)have been detected at different stages of follicular development and in different cells of follicles.Extracellular vesicle(EV)-derived miRNAs have also been detected in the follicular fluid of mature follicles.miRNAs participate in the regulation of normal follicular development,and the regulation disorder may lead to the occurrence of some ovarian diseases.In order to further systematically elucidate the regulatory mechanism of miRNAs on follicular development and find suitable EV-derived miRNAs that can predict oocyte development,we reviewed the functions of miRNAs in follicular development from the perspectives of granulosa cell development,oocyte development,and hormone synthesis.

关 键 词：小RNA 卵泡发育 颗粒细胞 卵母细胞 激素合成 

分 类 号：R394.2[医药卫生—医学遗传学]