根除Hp四联疗法对非酒精性脂肪肝病合并Hp感染者的疗效  

Efficacy of Hp eradication quadruple therapy on patients with nonalcoholic fatty liver disease complicated with Hp infection

作　　者：仓艳燕 周朝阳 CANG Yan-yan(Department of Internal Medicine,Second People's Hospital of Xinzheng Zhengzhou,Henan 450000,China)

机构地区：[1]新郑市第二人民医院内二科 [2]新郑市人民医院神经外科,河南郑州450000

出　　处：《牡丹江医学院学报》2021年第5期35-38,共4页Journal of Mudanjiang Medical University

摘　　要：目的探讨根除Hp的四联疗法对非酒精性脂肪肝病(NAFLD)合并幽门螺杆菌(Hp)感染患者血脂水平及肝功能的影响。方法选取我科2018年1月至2019年10月间135例非酒精性脂肪肝病(NAFLD)合并幽门螺杆菌(Hp)感染患者作为研究对象,根据随机数字表法分组,分为对照组和观察组。对照组67例给予多烯磷脂酰胆碱胶囊联合二甲双胍治疗,观察组68例增加根除Hp四联疗法治疗:奥美拉唑肠溶胶囊+阿莫西林胶囊+克拉霉素胶囊+胶体果胶铋胶囊,四联疗法持续2周,全部患者的既定疗程均为2个月,对比两组患者有效率、Hp根除率,治疗前后血脂水平与肝功能:ALT、AST、TG、TC、LDL;氧化应激因子:丙二醛(MDA)、超氧化物歧化酶(SOD)水平;不良反应。结果治疗后观察组ALT、AST、TG、TC、LDL、MDA均低于对照组,SOD水平、根除Hp率高于对照组,总有效率98.59%高于对照组70.15%,有明显差异(P<0.05);观察组不良反应发生率8.82%高于对照组5.97%,无明显差异(P>0.05)。结论根除Hp的四联疗法对NAFLD合并Hp感染患者治疗,可改善肝功能和血脂水平,提高Hp感染根除率和临床疗效,药物安全性高。Objective To investigate the effect of quadruple therapy for eradication of Hp on blood lipid levels and liver function in patients with non-alcoholic fatty liver disease(NAFLD) complicated with Helicobacter pylori(Hp) infection. Methods From January 2018 to October 2019,135 patients with non-alcoholic fatty liver disease(NAFLD) complicated with Helicobacter pylori(Hp) infection were selected as the research subjects. They were grouped according to the random number table method and divided into a control group and an observation group. 67 cases in the control group were given polyene phosphatidylcholine capsules combined with metformin, and 68 cases in the observation group were treated with Hp eradication therapy: omeprazole enteric-coated capsules+amoxicillin capsules+clarithromycin capsules+colloidal bismuth pectin Capsules, quadruple therapy lasted 2 weeks, the planned course of treatment for all patients was 2 months, comparing the effectiveness, Hp eradication rate, blood lipid levels and liver function before and after treatment: ALT,AST,TG,TC,LDL;oxidation Stress factors: malondialdehyde(MDA),superoxide dismutase(SOD) levels;adverse reactions. Results After treatment, the observation group ALT,AST,TG,TC,LDL,MDA were lower than the control group, SOD level, Hp eradication rate was higher than the control group, the total effective rate was 98.59% higher than the control group 70.15%,there was a significant difference(P<0.05);the incidence of adverse reactions in the observation group was 8.82% higher than that in the control group, 5.97%,with no significant difference(P>0.05). Conclusion The quadruple therapy for eradication of Hp can improve the liver function and blood lipid levels of patients with NAFLD combined with Hp infection, improve the eradication rate and clinical efficacy of Hp infection, and have high drug safety.

关 键 词：四联疗法 非酒精性脂肪肝病 幽门螺杆菌感染 肝功能 血脂水平 

分 类 号：R575.5[医药卫生—消化系统]