PCAF and SIRT1 modulateβTrCP1 protein stability in an acetylation-dependent manner  

作　　者：Fabin Dang Cong Jiang Tao Zhang Hiroyuki Inuzuka Wenyi Wei 

机构地区：[1]Department of Pathology,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA 02215,USA

出　　处：《Journal of Genetics and Genomics》2021年第7期652-655,共4页遗传学报（英文版）

基　　金：supported in part by 1K99CA263194 to F.D.,R01CA229307,R35CA253027 to W.W。

摘　　要：Ubiquitination plays critical roles in regulating various physiological events,such as protein degradation,activation,secretion,sorting and trafficking(Dang et al.,2021).The ubiquitination process involves three major steps,catalyzed by ubiquitin-activating enzymes(E1s),ubiquitin-conjugating enzymes(E2s),and ubiquitin ligases(E3s),respectively(Scheffner et al.,1995).

关 键 词：STABILITY STEPS CATALYZED 

分 类 号：Q75[生物学—分子生物学]