基于AJCC分期标准下Ⅰ~Ⅲ期乳腺癌微小RNA-21和程序性细胞死亡因子4的表达及超声征像分析  

Expression of MicroRNA-21 and Programmed Cell Death Factor 4 and Ultrasound Feature in StageⅠ~ⅢBreast Cancer Based on AJCC Staging Criteria

作　　者：马琼 李安洋 周理好 MA Qiong;LI An-yang;ZHOU Li-hao(Affiliated Hospital of Wanxi Health Vocational College,Luan 237000,China)

机构地区：[1]皖西卫生职业学院附属医院,安徽六安237000

出　　处：《肿瘤学杂志》2021年第9期747-751,共5页Journal of Chinese Oncology

基　　金：安徽省教育厅高校自然科学研究重点项目(KJ2017A910)。

摘　　要：[目的]探讨基于美国癌症联合委员会(AJCC)第八版预后分期标准下不同分期乳腺癌微小RNA-21(microRNA-21,miR-21)、程序性细胞死亡因子4(programmed cell death factor 4,PDCD4)表达差异性,并分析其超声特征。[方法]选择皖西卫生职业学院附属医院2017年12月至2020年12月经病理学确诊为乳腺癌118例,通过免疫组化和聚合酶链反应检测癌组织和癌旁正常组织中miR-21和PDCD4的表达,分析乳腺癌miR-21和PDCD4表达差异及与超声特征间的关系。[结果]Ⅰ~Ⅲ期乳腺癌miR-21及PDCD4表达水平差异显著,分期越晚,miR-21水平越高,PDCD4水平越低,差异均有统计学意义(P<0.05)。miR-21和PDCD4在乳腺癌中的表达呈负相关(P<0.05)。乳腺癌中miR-21高表达和PDCD4低表达与彩色多普勒超声检测到的边缘毛刺征、微钙化、肿瘤血供分级和淋巴结转移有关(P均<0.05)。[结论]基于AJCC分期标准下Ⅰ~Ⅲ期乳腺癌miR-21和PDCD4表达水平差异显著,动态监测miR-21和PDCD4的表达水平有助于评估乳腺癌患者个体化治疗效果及预后。对微钙化、边缘毛刺征、肿瘤血供分级和淋巴结转移超声特征进行综合考虑将有助于对乳腺癌患者预后作出初步判断。[Objective]To investigate the expression of micro RNA-21(mi R-21)and programmed cell death factor 4(PDCD4)in breast cancer stageⅠ~Ⅲbased on the American Joint Commission on cancer(AJCC)8 th Edition prognostic staging criteria,and their relationship with ultrasound features.[Methods]A total of 118 patients with breast cancer staged by AJCC criteria in the Affiliated Hospital of Wanxi Health Vocational College from December 2017 to December 2020 were enrolled in the study.The expression of mi R-21 and PDCD4 in cancer tissues and adjacent normal tissues were detected by immunohistochemistry and polymerase chain reaction.The expression differences of mi R-21 and PDCD4 in stageⅠ~Ⅲbreast cancer and their relationship with ultrasound features were analyzed.[Results]The expression levels of mi R-21 and PDCD4 in stageⅠ,ⅡandⅢbreast cancer were significantly different,and the stage was positively correlated with mi R-21 expression level and negatively correlated with PDCD4 level(P all<0.05).The expression of mi R-21 and PDCD4 in breast cancer was negatively correlated with each other(P<0.05).The color Doppler ultrasonography of patients with high mi R-21 expression and low PDCD4 expression were likely to present edge spicule sign,microcalcification and high degree blood supply.[Conclusion]The expression levels of mi R-21 and PDCD4 in AJCC stageⅠ~Ⅲbreast cancer are significantly different.The comprehensive consideration of microcalcification,spicule signn,tumor blood supply grade and lymph node metastasis on ultrasonography will help to make a preliminary judgment of the prognosis of breast cancer patients.

关 键 词：乳腺癌 微小RNA-21 程序性细胞死亡因子4 超声特征 

分 类 号：R737.9[医药卫生—肿瘤]