Notch配体JAG1在乳腺癌中的研究进展  

Research Progress on Notch Ligand JAG1 in Breast Cancer

作　　者：孙维廷 刘彩霞[2] SUN Wei-ting;LIU Cai-xia(Inner Mongolia Medical University,Hohhot 010050,China;Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院,内蒙古呼和浩特010050

出　　处：《肿瘤学杂志》2021年第9期766-771,共6页Journal of Chinese Oncology

基　　金：内蒙古自治区自然科学基金面上项目(2019MS08018)。

摘　　要：JAG1是Notch信号通路5种细胞表面配体之一,在乳腺癌发病中起着重要的作用。研究发现JAG1在正常乳腺及乳腺癌中均有表达,且其阳性表达率与乳腺癌的分子分型有关,不同人乳腺肿瘤细胞系中JAG1基因和蛋白的表达水平也不同。JAG1表达升高与肿瘤大小、分化程度、雌激素和孕激素受体阴性率、脑转移、骨转移呈正相关,提示JAG1是乳腺癌复发和预后不良的独立预测因子,也是更具侵袭性乳腺癌的特征。此外有研究发现JAG1作为抗肿瘤治疗的靶点具有许多优势,靶向JAG1可能为乳腺癌提供一个更大的治疗窗口,与其他治疗手段的联合应用也是未来探索的方向。JAG1 is one of the five cell surface ligands of Notch signaling pathway and plays an important role in the pathogenesis of breast cancer.Some studies have found that JAG1 is expressed in both normal breast and breast cancer,and its positive expression rate is related to the molecular typing of breast cancer.The expression levels of JAG1 gene and protein are also different in different human breast tumor cell lines.At the same time,it was found that the increased expression of JAG1 was positively correlated with tumor size,degree of differentiation,negative rate of estrogen and progesterone receptor,brain metastasis and bone metastasis,suggesting that JAG1 is an independent predictor of recurrence and poor prognosis of breast cancer,and it is also a more characteristic of invasive breast cancer.In addition,some studies have found that JAG1 as a target for anticancer therapy has many advantages,targeting JAG1 may provide a larger treatment window for breast cancer,and the combination with other treatments is also the direction of future exploration.

关 键 词：乳腺癌 JAG1 侵袭性 预后 治疗 

分 类 号：R737.9[医药卫生—肿瘤]