邯郸地区非综合征唇腭裂患儿母亲孕期危险因素分析  

Maternal environmental risk factors for nonsyndromic cleft lip and/or palate

作　　者：柴丛娜[1] 焦建军[1] 程磊 党娟 靳书滨[1] 石光 CHAI Congna;JIAO Jianjun;CHENG Lei;DANG Juan;JIN Shubin;SHI Guang(Handan Central Hospital,Handan 056000)

机构地区：[1]河北省邯郸市中心医院,056000 [2]河北省邯郸市口腔医院

出　　处：《现代口腔医学杂志》2021年第5期313-316,共4页Journal of Modern Stomatology

基　　金：河北省医学科学研究课题计划(20200451)。

摘　　要：目的探讨母亲孕期危险因素和河北邯郸地区非综合征唇腭裂患儿之间的关系。方法本文采用回顾性病例对照研究的方法,选取唇腭裂患者376例,同期选取345例无唇腭裂患儿作为对照组,两组年龄和性别相匹配,研究人员通过查询医学记录,随访病例组及对照组母亲孕期环境危险因素,并填写调查问卷,采用卡方检验及logistic多因素回归分析的方法,对数据进行统计分析。结果唇腭裂患者的孕期高危因素有:母亲年龄高[OR3.709;95%CI3.421~5.496],P=0.005、母亲教育水平低[OR1.549;95%CI1.194~2.643],P=0.005、孕期被动吸烟[OR2.793;95%CI2.186~3.497],P=0.005、母亲孕期感冒或发热[OR1.167;95%CI1.602~4.073],P=0.005、多来自农村(P=0.01),孕期营养不良(P=0.001)、患儿早产(P=0.05)显著增加非综合征性唇腭裂发病风险。补充叶酸及维生素[OR0.130;95%CI1.809~4.375],P=0.005、适当的母亲年龄和较高的母亲教育可降低非综合征唇腭裂风险。结论邯郸地区非综合征唇腭裂患儿母亲孕期危险因素为母亲年龄高,母亲受教育水平低,孕期营养不良,孕期感冒发烧,孕期被动吸烟,胎儿早产。而母亲孕期补充叶酸、适宜生育年龄、高文化程度是邯郸地区非综合征唇腭裂的保护因素。Objective To evaluate the association between environmental factors and nonsyndromic cleft of the lip and/or palate(NSCL/P)in Handan District,China.Methods A retrospective case-control study was carried out.A total of 376 NSCL/P children were selected as cases;345 controls were chosen from other diagnosis in the same department during the same period.The 2 groups matched age and sex.The researchers followed up the maternal environmental risk factors during pregnancy in the case group and the control group,filled in questionnaires,and statistically analyzed the data using chi-square test and logistic multifactor regression analysis.Results High risk factors of cleft lip and palate patients during pregnancy include:Maternal age was higher[OR3.709;95%CI3.421~5.496],P=0.005,maternal education level was lower[OR1.549;95%CI1.194~2.643],P=0.005,passive smoking during pregnancy[OR2.793;95%CI2.186~3.497],P=0.005,cold or fever during pregnancy in mothers[OR1.167;95%CI1.602~4.073],P=0.005,mostly from rural areas(P=0.01),Malnutrition(P=0.001)and premature birth(P=0.05)significantly increased the risk of non-syndromic cleft lip and palate.Folic acid and vitamin supplementation[OR0.130;95%CI1.809~4.375],P=0.005,appropriate maternal age,and higher maternal education reduced the risk of non-syndromic cleft lip and palate.Conclusion The maternal risk factors of non-syndromic cleft lip and palate children in Handan area were high maternal age,low maternal education level,malnutrition during pregnancy,cold and fever during pregnancy,passive smoking during pregnancy,and premature birth.Folic acid supplementation during pregnancy,suitable age for childbirth and high educational level were the protective factors for non-syndromic cleft lip and palate in Handan area.

关 键 词：非综合征性唇腭裂 危险因素 环境暴露 

分 类 号：R782.2[医药卫生—口腔医学]