ω-3鱼油脂肪乳对腹腔镜辅助胃癌根治术后影响的研究  

Effect of omega-3 fish oil fat emulsion on laparoscopic assisted radical operation for gastric cancer

作　　者：程康文 马冬花 孙陟 王亚娟[1] 王洁[3] 左贵泽 王贵和[1] CHENG Kangwen;MA Donghua;SUN Zhi(Department of Gastrointestinal Surgery,Tongling people’s Hospital,Anhui,Tongling 244000,China)

机构地区：[1]安徽省铜陵市人民医院胃肠外科,244000 [2]安徽省铜陵市人民医院护理部,244000 [3]安徽省铜陵市人民医院东部院区外科,244000

出　　处：《临床外科杂志》2021年第9期853-856,共4页Journal of Clinical Surgery

摘　　要：目的探讨ω-鱼油脂肪乳对腹腔镜辅助胃癌根术后临床结局的影响。方法2018年2月~2019年10月期间我院胃肠外科行腹腔镜辅助胃癌根治术的病人80例,电脑随机分为研究组和对照组。研究组从术后第1天开始在肠外营养中添加10%的鱼油脂肪乳剂100 ml;对照组术后采取常规治疗措施。比较两组术后恢复指标、术后肠内营养实际鼻饲量及相关并发症、术后手术相关并发症的发生情况。结果共计80例病人完成研究,研究组40例,对照组40例。两组病人术后首次通气时间、术后首次排便时间、术后住院时间及住院总费用比较差异均无统计学意义(P>0.05)。研究组术后4天、术后5天及术后6天实际肠内营养鼻饲量均大于对照组,差异有统计学意义(均P<0.05);研究组恶心和腹胀发生率[17.5%(7/40)和37.5%(15/40)]均低于对照组[27.5%(11/40)和70.0%(28/40)],两组比较,差异均具有统计学意义(P<0.05)。研究组感染性并发症发生率低于对照组,两组比较,差异有统计学意义(P<0.05);研究组非感染性并发症发生率与对照组比较,差异无统计学意义(P>0.05)。结论腹腔镜辅助胃癌根治术后使用鱼油脂肪乳可以提高肠内营养的耐受性,降低术后感染性并发症的发生率。Objective To investigate the effect of fish oil fat emulsion on clinical outcome of laparoscopic assisted radical operation for gastric cancer.Methods From June 2018 to September 2019,undergoing laparoscopic assisted radical resection of gastric cancer patients were randomly divided into experimental group and control group.From the first day after operation,10%fish oil fat emulsion 100 mL was added to parenteral nutrition in the experimental group,and the patients in the control group were treated with routine treatment after operation.The occurrence of postoperative recovery index,the actual nasal feeding volume of postoperative intestinal nutrition and related complications,and the complications related to postoperative surgery were compared.Results A total of 80 patients completed the study.There were 40 cases in the experimental group and 40 cases in the control group.There was no statistical difference in the first ventilation time,the first defecation time,the postoperative hospitalization time and the total hospitalization cost between the two groups(P>0.05).On the 4 st,5 rd and 6 th day after operation,the actual amount of enteral nutrition nasal feeding in the experimental group was higher than that in the control group,the difference was statistically significant(all P<0.05);compared with the control group,the incidence of nausea[17.5%(7/40)and 37.5%(15/40)],abdominal distension were lower[27.5%(11/40)and 70.0%(28/40)],the differences were statistically significant(all P<0.05).The incidence of total infectious complications in the experimental group was significantly lower than that in the control group(P<0.05),but there was no significant difference in the incidence of total non-infectious complications between the experimental group and the control group(P>0.05).Conclusion Using fish oil fat emulsion after laparoscopic assisted radical resection of gastric cancer can improve tolerance to enteral nutrition,and reduce the occurrence of postoperative total infectious complications.

关 键 词：Ω-3鱼油脂肪乳 胃肿瘤 胃癌 胃切除术 腹腔镜 

分 类 号：R735.2[医药卫生—肿瘤]