近视患者角膜在体与离体生物力学特性相关性初步研究  

Correlation of corneal biomechanical properties of myopic patients in vivo and in vitro

作　　者：薛超[1] 王雁[1] 向尧齐 沈岷[2] 吴迪[1] XUE Chao;WANG Yan;XIANG Yaoqi;SHEN Min;WU Di(Tianjin Eye Hospital,Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin Eye Institute,Clinical College of Ophthalmology,Tianjin Medical University,Tianjin 300020,China;School of Mechanical Engineering,Tianjin University,Tianjin 300020,China)

机构地区：[1]天津市眼科医院,天津市眼科学与视觉科学重点实验室,天津市眼科研究所,天津市300020 [2]天津大学机械工程学院,天津市300020

出　　处：《眼科新进展》2021年第10期943-947,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金项目(编号81670884)。

摘　　要：目的探讨近视患者角膜在体与离体生物力学参数的关系。方法对拟行飞秒激光小切口角膜基质透镜取出术(SMILE)的近视患者术前利用Corvis ST角膜生物力学分析仪行在体角膜生物力学参数测量,术后将术中获取的角膜基质透镜进行单轴拉伸试验来获取其离体生物力学参数。采用Pearson相关分析法探讨近视患者角膜在体与离体生物力学参数的关系。结果近视患者离体角膜基质在应力为0.02 MPa时,对应的弹性模量为(1.26±0.71)MPa。相关性分析结果表明,弹性模量与Corvis ST角膜生物力学分析仪测量得到的17个在体动态角膜反应参数中的14个参数均显著相关;回归分析得到的回归方程为弹性模量=-49.470+9.188A1Time+9.946A1Velocity-0.195DefAMax(ms)+0.077SP-HCA1Time第1次压平时间,A1Velocity第1次压平速度,DefAMax最大的偏离幅度(ms),SP-HC最大凹陷时角膜硬度参数,回归模型具有统计学意义(F=883.948,P=0.000)。结论近视患者角膜基质弹性模量可以通过在体角膜生物力学参数测量结果初步推算。Objective To investigate biomechanical properties of cornea of myopic patients in vivo and in vitro.Methods The in vivo biomechanical measurements were performed using CorvisST corneal biomechanics analyzer in myopic patients before femtosecond small incision lenticule extraction(SMILE)surgery.After the SMILE surgery,strip specimens cut from corneal stromal lenticule were subjected to in vitro measurements with the uniaxial tensile test.The relationship between the in vivo biomechanical parameters and the in vitro mechanical parameters of the cornea was obtained by Pearson correlation method.Results The value of elastic modulus was(1.26±0.71)MPa with in vitro test at the stress of 0.02 MPa.Elastic modulus was significantly correlated with 14 of 17 in vivo dynamic corneal response(DCR)parameters.The regression equation E=-49.470+9.188A1Time+9.946A1Velocity-0.195 DefAMax(ms)+0.077SP-HC was obtained.The regression model had statistical significance(F=883.948,P=0.000).Conclusion Elastic modulus estimations of corneal stroma of myopic patients can be obtained from in vivo mechanical measurements,and further research with a large sample size is still needed.

关 键 词：角膜 生物力学特性 单轴拉伸试验 Corvis ST角膜生物力学分析仪 

分 类 号：R778.1[医药卫生—眼科]