SARS-CoV-2对眼部的影响及其经眼途径传播的可能性  

Ocular influence and possibility of ocular transmission of SARS-CoV-2

作　　者：黄小娜 黄艳君 邵东平 HUANG Xiaona;HUANG Yanjun;SHAO Dongping(Department of Ophthalmology,Nanhai Hospital Affiliated to Southern Medical University,Foshan 528200,Guangdong Province,China)

机构地区：[1]南方医科大学附属南海医院眼科,广东省佛山市528200

出　　处：《眼科新进展》2021年第10期996-1000,共5页Recent Advances in Ophthalmology

摘　　要：SARS-CoV-2引起的新型冠状病毒肺炎(COVID-19)已对全球构成重大的公共卫生威胁。SARS-CoV-2和SARS-CoV均属于人冠状病毒(HCoVs)β属,两者的基因组相似性高达79.6%,且均通过血管紧张素转换酶2(ACE-2)感染宿主细胞。目前已有研究表明,SARS-CoV-2感染与结膜炎具有一定相关性,SARS-CoV-2是否能经眼感染或传播的问题也备受关注,但目前尚缺乏其通过眼部组织感染的临床确诊病例和实验室证据。本文就SARS-CoV-2的病原学特点、流行病学特征、眼部表现及结膜囊病毒感染率作一综述,并对SARS-CoV-2经眼途径传播的可能性进行探讨。The corona virus disease 2019(COVID-19)pandemic induced by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a major global public health threat.Both the SARS-CoV-2 and SARS-CoV etiologic agents belong to the subfamily of beta human coronavirus,and their genomic similarity is up to 79.6%.Both SARS-CoV and SARS-CoV-2 infect the host cell through angiotensin converting enzyme-2.At present,it has been shown that SARS-CoV-2 infection is associated with conjunctivitis.Therefore,that whether the SARS-COV-2 can be infected or transmitted through the eye is also of great concern,but it still a lack of clinically confirmed cases and laboratory evidence of its ocular transmission.This review focuses on the etiological characteristics,epidemiologic features,ocular presentation of SARS-CoV-2 and the conjunctival sac infection rate,and the possibility of SARS-CoV-2 transmission through the ocular tissue will be discussed.

关 键 词：SARS-CoV-2 眼部表现 结膜囊感染率 眼途径传播 

分 类 号：R777.3[医药卫生—眼科]