The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders  

作　　者：Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua 

机构地区：[1]Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore [2]LSI Neurobiology Programme,National University of Singapore,Singapore,Singapore [3]Institute for Health Innovation and Technology,National University of Singapore,Singapore,Singapore [4]Healthy Longevity Translational Research Program,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore [5]Institute of Molecular and Cell Biology,Agency for Science,Technology and Research(A*STAR),Singapore,Singapore

出　　处：《Neural Regeneration Research》2022年第6期1165-1171,共7页中国神经再生研究（英文版）

基　　金：the Singapore Ministry of Education(T1-2015 Apr-03);the National University of Singapore;Institute for Health Innovation and Technology to JJEC.

摘　　要：The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly.These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions.Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders.Supporting this notion,efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation,maturation,synaptogenesis and synaptic function.Fasciculation and elongation protein zeta-1,a Kinesin-1 adapter,has emerged as a key central player involved in many of these processes.Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment.Furthermore,it acts downstream of guidance cue pathways to regulate axo-dendritic development.Significantly,perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system.Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders.Moreover,altered phosphorylation of the protein contributes to neurodegenerative disorders.Together,these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.

关 键 词：fasciculation and elongation protein zeta-1 neurological disorder neuronal development neuronal differentiation neuronal networks synapse formation synaptic function 

分 类 号：R749.1[医药卫生—神经病学与精神病学]