Mechanosensitivity of N-methyl-D-aspartate receptors(NMDAR)is the key through which amyloid beta oligomers activate them  

作　　者：Giulia Fani Fabrizio Chiti 

机构地区：[1]Department of Experimental and Clinical Biomedical Sciences,Section of Biochemistry,University of Florence,Florence,Italy

出　　处：《Neural Regeneration Research》2022年第6期1263-1264,共2页中国神经再生研究（英文版）

基　　金：Regione Toscana(FAS-Salute 2014;Project Supremal and FAS-Salute 2018;Project PRAMA)(to FC).

摘　　要：Alzheimer’s disease(AD)is one of the major forms of dementia,accounting for 60 to 80%of the cases of dementia,affecting approximately 50 million people worldwide,which is why it has become an object of great interest in both the medical and social fields(Source:Alzheimer’s Association).One of the main histopathological hallmarks of AD is the formation and accumulation of senile plaques in the brain parenchyma,mainly composed by fibrillar aggregates of the amyloidβ(Aβ)peptide.This peptide is generated by the cleavage of the membrane protein named amyloidβprecursor protein,and its secretion in the extracellular space leads to its aggregation into amyloid fibrils.Various intermediates of this process of aggregation have been identified,and it was found that prefibrillar,soluble oligomeric forms of Aβare more likely to be the pathological species(Benilova et al.,2012).

关 键 词：AMYLOID Alzheimer Aβ 

分 类 号：R749.16[医药卫生—神经病学与精神病学]