机构地区:[1]首都医科大学附属北京友谊医院普通外科国家消化系统疾病临床医学研究中心,100050
出 处:《中华消化外科杂志》2021年第10期1091-1097,共7页Chinese Journal of Digestive Surgery
基 金:国家科技支撑计划(2015BAI13B09);国家重点研发计划(2017YFC0110904);首都医科大学结直肠肿瘤临床诊疗与研究中心项目(1192070313)。
摘 要:目的探讨全身免疫炎症评分(SII)与结直肠癌临床病理特征的相关性。方法采用回顾性队列研究方法。收集2019年2月至2021年5月首都医科大学附属北京友谊医院收治的513例结直肠癌病人的临床病理资料;男311例,女202例;年龄为(64±12)岁。观察指标:(1)结直肠癌病人SII情况及其与临床病理特征的相关性分析。(2)结直肠癌病人SII的影响因素分析。以SII中位数为截断值,将病人分为高SII和低SII病人进行分析。正态分布的计量资料以x±s表示,组间比较采用t检验。计数资料以绝对数或百分比表示,组间比较采用χ^(2)检验。偏态分布的计量资料以M(P25,P75)表示,组间比较采用非参数秩和检验。等级资料比较采用Mann-Whitney U非参数检验。选取组间比较差异有统计学意义的变量进一步分析。其中计量资料采用Pearson相关系数分析,等级资料采用Wilcoxon或Kruskal-Willas分析并进行Bonferroni校正。采用线性回归进行单因素和多因素分析。结果(1)结直肠癌病人SII情况及其与临床病理特征的相关性分析:513例病人的SII为355(253,507)。513例病人以SII中位数355为截断值,257例SII>355为高SII,256例SII≤355为低SII。高SII病人Karnofsky功能状态(KPS)评分,术前白蛋白(Alb),CA125,肿瘤位置(左半结肠、右半结肠),肿瘤长径、手术方式(腹腔镜辅助、开腹),病理学T分期(T0期、T1期、T2期、T3期、T4期),病理学TNM分期(Ⅰ、Ⅱ、Ⅲ、Ⅳ期)分别为(87±17)分,(37±5)g/L,8.80 U/mL(5.90 U/mL,14.15 U/mL),174、83例,(5.2±2.8)cm,208、44例,5、19、25、131、63例,34、98、94、14例;低SII病人上述指标分别为(91±13)分,(38±4)g/L,7.20 U/mL(5.40 U/mL,10.03 U/mL),200、56例,(4.0±1.9)cm,221、24例,8、39、35、118、45例,61、84、79、12例,两者上述指标比较,差异均有统计学意义(t=-2.770、-3.211,Z=-3.799,χ^(2)=7.050,t=5.324,χ^(2)=6.179,Z=-3.390、-2.227,P<0.05)。Pearson相关系数分析结果显示:SII与肿Objective To investigate the relationship between systematic immune-inflamma-tion index(SII)and clinicopathological characteristics for colorectal cancer.Methods The retrospec-tive cohort study was conducted.The clinicopathological data of 513 patients with colorectal cancer who were admitted to the Beijing Friendship Hospital of Capital Medical University from February 2019 to May 2021 were collected.There were 311 males and 202 females,aged(64±12)years.Observation indicators:(1)SII of colorectal cancer and relationship between SII and clinicopatholo-gical characteristics;(2)influencing factors for SII in colorectal cancer patients.According to the median of SII as the cutoff value,the patients were divided into high SII and low SII patients.Measurement data with normal distribution were represented as Mean±SD,and comparison between groups was analyzed using the t test.Count data were represented as absolute numbers or percen-tages,and comparison between groups was conducted using the chi-square test.Measurement data with skewed distribution were represented as M(P25,P75),and comparison between groups was analyzed using the non-parameter rank sum test.Comparison of ordinal data was analyzed using the Mann-Whitney U non-parameter test.Variables with statistically significant differences between groups were included for further analysis.Pearson correlation coefficient analysis was used for continuous data,and Wilcoxon or Kruskal-Willas analysis was used for categorical data and Bonferroni correction was performed.Univariate and multivariate linear regression analyses were conducted.Results(1)SII of colorectal cancer and relationship between SII and clinicopathological charac-teristics:the SII of 513 patients was 355(253,507).Taking the median SII 355 as the cutoff value,257 of 513 patients with SII>355 had high SII and 256 cases with SII≤355 had low SII.Of high SII patients,the Karnofsky performance status(KPS)score,preoperative albumin(Alb),CA125,cases with tumor located at left or right hemicolon,tumor diame
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