临界闪烁融合频率在非动脉炎性前部缺血性视神经病变中的临床应用  

Clinical application of critical flicker fusion frequency in non-arteritic anterior ischemic optic neuropathy

作　　者：付俊霞 李晓明[1,2] 王永平[1] 周欢粉[1] 徐全刚[1] 魏世辉[1] Fu Junxia;Li Xiaoming;Wang Yongping;Zhou Huanfen;Xu Quangang;Wei Shihui(Department of Ophthalmology,The Chinese People’s Liberation Army General Hospital&The Chinese People’s Liberation Army Medical School,Beijing 100853,China;the Department of Ophthalmology,Jilin Province People's Hospital,Changchun 130021,China)

机构地区：[1]解放军总医院眼科医学部,北京100853 [2]吉林省人民医院眼科,长春130021

出　　处：《中华眼底病杂志》2021年第10期769-774,共6页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的初步探讨临界闪烁融合频率(CFF)在非动脉炎性前部缺血性视神经病变(NAION)中的应用价值。方法横断面研究。2021年1~9月于解放军总医院第一医学中心眼科检查确诊的NAION患者58例105只眼(NAION组)和同期健康对照者33名63只眼(HC组)纳入研究。受检者行最佳矫正视力(BCVA)、光相干断层扫描(OCT)、视野、CFF、闪光视觉诱发电位(F-VEP)检查。采用Snellen小数视力表行BCVA检查,统计时换算为最小分辨角对数视力。NAION组56例72只眼,包括男性31例43只眼,女性25例29只眼;平均年龄(49.28±11.42)岁。按照发病至行CFF检查的时间间隔,将发病时间分为<1、1~<3、3~<6、>6个月,分别为20(27.8%)、26(36.1%)、17(23.6%)、9(12.5%)只眼。按照CFF检查时BCVA≥0.5、0.1~0.5、<0.1将NAION分为轻度、中度、重度,分别为33(45.8%)、32(44.4%)、7(9.8%)只眼。HC组33例63只眼,包括男性17例31只眼,女性16例32只眼;平均年龄(35.18±10.96)岁。采用日本NEITZ公司手持式CFF检测仪2型行CFF检查。记录CFF检查1周内受检眼视盘周围视网膜神经纤维层(pRNFL)厚度、黄斑内界膜至视网膜色素上皮层(mILM-RPE)厚度、F-VEP峰时和峰值、视野平均缺损(MD)值。不同检查时间点和不同程度NAION患眼CFF值比较行单因素方差分析。采用Pearson相关性分析法分析CFF与F-VEP峰时、峰值、BCVA和视野MD值的相关性。结果NAION组患眼CFF-红色、绿色、黄色值分别(22.56±10.30)、(24.10±11.51)、(24.81±11.41)Hz。与HC组比较,NAION组患眼CFF-红色、绿色、黄色值均明显减低,差异均有统计学意义(t=-10.53、-11.11、-11.36,P<0.05)。发病后不同时间点CFF-红色、绿色、黄色值比较,差异无统计学意义(F=2.075、1.893、2.073,P>0.05);不同程度NAION患眼CFF-红色、绿色、黄色值比较,差异有统计学意义(F=31.579、27.332、32.055,P<0.05)。相关性分析结果显示,患眼F-VEP峰时(r=-0.362、-0.379、-0.357,P<0.05)、BCVA(r=-0.705、-0Objective To investigate the application of critical flicker fusion frequency(CFF)in non-arteritic anterior ischemic optic neuropathy(NAION).Methods A cross-sectional study.From January 2021 to September 2021,a total of 58 NAION patients(105 eyes)(NAION group)and 33 cases(63 eyes)in the healthy control(HC)group were included from Department of Ophthalmology of First Medical Center,PLA General Hospital.Patients underwent best-corrected visual acuity(BCVA),optical coherence tomography(OCT),visual field,CFF and flash visual evoked potential(F-VEP)examinations.BCVA examination was performed using a Snellen decimal visual acuity chart and was converted to logarithm of the minimum angle of resolution visual acuity.In the affected eyes group,there were 56 cases(72 eyes),31 cases(43 eyes)male and 25 cases(29 eyes)female,with an average age of 49.28±11.42 years old.And the affected eyes were divided into 4 groups:<1,1-<3,3-<6 and>6 months according to the time interval from onset to CFF examination,which were 20(27.8%),26(36.1%),17(23.6%)and 9(12.5%)eyes,respectively.According to the BCVA≥0.5,0.1-0.5,<0.1 in CFF examination,the affected eyes were divided into a mild,moderate,and severe degree,33(45.8%),32(44.4%)and 7(9.8%)eyes,respectively.Sixty-three eyes of 33 cases were in the HC group.There were 17 cases(31 eyes)males and 16 cases(32 eyes)females,with an average age of 35.18±10.96 years.Hand-held CFF detector type 2(Japan,NEITZ company)was used for the CFF examination.The thickness of peripheral retinal nerve fiber layer(pRNFL),macular inner limiting membrane retinal pigment epithelium(mILM-RPE),F-VEP peak time and peak value and mean visual field defect(MD)values were recorded within 1 week of CFF examination.The CFF value of the above subgroups was analyzed in order using one-way ANOVA.Pearson correlation analysis was used for the correlation between CFF and F-VEP peak time,peak value,BCVA and MD.The correlations between BCVA,visual field,F-VEP,and CFF were analyzed.Results The trichromatic values of red,green a

关 键 词：视神经病变 缺血性 临界闪烁融合频率 

分 类 号：R774.6[医药卫生—眼科]