Atypical spindle cell lipomatous tumor/atypical pleomorphic lipomatous tumor and atypical mammary-type myofibroblastoma: clinicopathological, immunohistochemical, and multiplex fluorescence in situ hybridization analyses  

作　　者：Zhang Zhang Nan Liu Min Chen Ran Peng Hui-Jiao Chen Hong-Ying Zhang 

机构地区：[1]Department of Pathology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Pathology,The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China

出　　处：《Chinese Medical Journal》2021年第19期2370-2372,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81972520 and 81472510);the Key R&D(Major Science and Technology Project)Project of Sichuan Science and Technology Department(No.2020YFS0270);the 135 Project for Disciplines of Excellence–Clinical Research Incubation Project,West China Hospital,Sichuan University(No.2018HXFH011).

摘　　要：To the Editor:Lipomatous neoplasms with spindle cell components and atypical features are rare soft tissue tumors.Atypical lipomatous tumor(ALT)/well-differentiated liposarcoma(WDLPS)is one of the most common liposarcomas with MDM2(12q13–15)gene amplification.However,recently,some studies have suggested that unique lipomatous tumors named“atypical spindle cell lipomatous tumor”(ASLT)and atypical pleomorphic lipomatous tumor(APLT)should be distinguished from WDLPS because they have a better prognosis.[1,2]ASLT and APLT are tumors with RB1 gene deletions and the same chromosomal alterations as classical spindle cell lipoma(SCL)/pleomorphic lipoma.[2]The latest edition of the“World Health Organization Classification of Tumors of Soft Tissue and Bone,fifth edition”formally introduced the names of ASLT/APLT[3];these tumors are rare among Chinese patients,and only a few small series of cases have been reported in Asia.

关 键 词：ATYPICAL neoplasms alterations 

分 类 号：R738.6[医药卫生—肿瘤]