血脑脊液屏障功能障碍与中枢神经系统疾病的相关性  

Correlation between the blood cerebrospinal fluid barrier dysfunction and central nervous system diseases

作　　者：李超 陈晓姝 张艳淑 LI Chao;CHEN Xiaoshu;ZHANG Yanshu(School of Public Health,North China university of Science and Technology,Tangshan 063210,Shandong,P.R.China;Occupational Diseases Hospital of Shandong First Medical University,Ji′nan 250062,Shandong,P.R.China)

机构地区：[1]华北理工大学公共卫生学院,河北唐山063210 [2]山东第一医科大学附属职业病医院,山东济南250062

出　　处：《滨州医学院学报》2021年第5期395-398,共4页Journal of Binzhou Medical University

基　　金：国家自然科学基金(82073598)。

摘　　要：中枢神经系统(CNS)受到血脑脊液屏障(BCSFB)的保护,可免受血液中有害物质的侵害。血脑脊液屏障主要由脉络丛(CP)单层上皮细胞组成,它将血源性物质与脑脊液分离。血脑脊液屏障功能障碍会诱导中枢神经系统功能紊乱,并导致多种神经系统疾病的发生。本文简要综述了血脑脊液屏障功能障碍和神经系统疾病的相关性。The central nervous system(CNS)is protected by blood cerebrospinal fluid barrier(BCSFB)from harmful substances in the blood.The BCSFB is mainly composed of a monolayer of choroid plexus(CP)epithelial cells,which separates blood derived substances from cerebrospinal fluid.Dysfunction of blood cerebrospinal fluid barrier can induce central nervous system dysfunction and lead to a variety of nervous system diseases.This article briefly reviews the role of blood cerebrospinal fluid barrier in nervous system diseases.

关 键 词：血脑脊液屏障 脉络丛 神经系统疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]